Prospects for nutritional interventions in the clinical management of Fanconi anemia.

Abstract

The evidence associating Fanconi anemia (FA) phenotype to in-vitro and ex-vivo oxidative stress is reviewed. A cancer-prone genetic disease, FA is characterized by delayed bone marrow failure with a progression to aplastic anemia. It is diagnosed by excess chromosomal instability induced by two clastogens, either diepoxybutane (DEB) or mitomycin C (MMC). Clinical symptoms vary in a broad range including a life-threatening hematological impairment, and an extended set of developmental abnormalities, growth retardation and skin pigmentation. Cancer-proneness in FA results in excess incidence of non-lymphoblastic leukemias, and of some defined solid tumors. The relationships of oxidative stress with FA phenotype rely on a consistent body of evidence that includes: (1) excess formation of DNA oxidative damage (both in vitro and in vivo); (2) cellular protection by hypoxia, low molecular-weight antioxidants, antioxidant enzymes, and thioredoxin overexpression; (3) impaired expression and/or activity of antioxidant enzymes, and (4) the redox-dependent action mechanisms of MMC and DEB. This evidence points to a re-appraisal of FA phenotype, suggesting a causative role for oxidative stress in disease progression towards malignancies and/or bone marrow depletion. A well-established literature reporting epidemiological and experimental data provides the nutritional bases for cancer control. Thus, the present state-of-the-art in the related fields of oxidative stress, nutrition, cancer-proneness and FA phenotype, altogether implies the need to undertake the most appropriate efforts to counteract oxidative stress in the clinical management of FA patients.

• Authors: G Pagano, L G Korkina
• Journal: Cancer causes & control : CCC (Cancer Causes Control) Vol. 11 Issue 10 Pg. 881-9 (Dec 2000) ISSN: 0957-5243 [Print] Netherlands
• PMID: 11142522 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibiotics, Antineoplastic
• Epoxy Compounds
• Mitomycin
• diepoxybutane

Topics

• Anemia, Aplastic (etiology, physiopathology)
• Antibiotics, Antineoplastic (pharmacology)
• Cell Transformation, Neoplastic
• Disease Progression
• Epoxy Compounds (pharmacology)
• Fanconi Anemia (metabolism, pathology, therapy)
• Humans
• Mitomycin (pharmacology)
• Nutritional Status
• Oxidative Stress
• Phenotype