Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues.

Abstract

We investigated immunohistochemically the localization of type 1 plasminogen activator inhibitor (PAI-1) in rat and human brain tissues. In rat, neurons and astrocytes were stained positively for PAI-1 after colchicine treatment. In post-mortem human brain, neurons were stained for PAI-1 but the number of positive neurons varied greatly from case to case. PAI-1 positive astrocytes occurred in the white matter lesions of some patients. In Alzheimer's disease, weak PAI-1 labeling was seen in association with senile plaques and ghost tangles. The present results support a notion that PAI-1 and its target proteases such as plasminogen activators and thrombin are involved in a variety of physiological and pathological processes in brain.

• Authors: H Hino, H Akiyama, E Iseki, M Kato, H Kondo, K Ikeda, K Kosaka
• Journal: Neuroscience letters (Neurosci Lett) Vol. 297 Issue 2 Pg. 105-8 (Jan 12 2001) ISSN: 0304-3940 [Print] Ireland
• PMID: 11121881 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Plasminogen Activator Inhibitor 1

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (metabolism, pathology)
• Animals
• Antibodies
• Astrocytes (chemistry)
• Brain (pathology)
• Brain Chemistry
• Fibrinolysis
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Neurofibrillary Tangles (chemistry, pathology)
• Neurons (chemistry)
• Plaque, Amyloid (chemistry, pathology)
• Plasminogen Activator Inhibitor 1 (analysis, immunology)
• Rats