Prophylactic implantable cardioverter defibrillator trials: MUSTT, MADIT, and beyond. Multicenter Unsustained Tachycardia Trial. Multicenter Automatic Defibrillator Implantation Trial.

Abstract

MUSTT and MADIT have clearly shown the survival benefit of an implantable cardioverter defibrillator (ICD) in patients with previous myocardial infarction, left ventricular ejection fraction < or = 0.40, and nonsustained ventricular tachycardia (VT), and who have had sustained VT induced at electrophysiology study. Progress in primary prevention of sudden cardiac death (SCD) depends on a concerted effort by clinicians to identify and appropriately treat MUSTT/MADIT-type patients; further research to more precisely define patient subgroups at risk for SCD and the willingness of industry to develop a lower priced ICD for prophylactic use are needed.

• Authors: E N Prystowsky, S Nisam
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 86 Issue 11 Pg. 1214-5, A5 (Dec 01 2000) ISSN: 0002-9149 [Print] United States
• PMID: 11090794 (Publication Type: Comment, Comparative Study, Editorial, Review)

Topics

• Clinical Trials as Topic
• Death, Sudden, Cardiac (etiology, prevention & control)
• Defibrillators, Implantable
• Humans
• Multicenter Studies as Topic
• Randomized Controlled Trials as Topic (methods)
• Risk Factors
• Tachycardia, Ventricular (complications, therapy)
• Ventricular Fibrillation (complications, therapy)