Lipid peroxidation in umbilical arterial blood at birth: the effects of breech delivery.

Abstract

OBJECTIVE:

To determine oxygen free radical activity in breech presentation at birth and relate it to umbilical cord blood acid-base status.

DESIGN:

A series of 63 singleton deliveries (28 cephalic deliveries as controls), 23 breech deliveries with normoacidemia, and 12 breech deliveries with mild acidaemia) had determination of malondialdehyde and acid-base parameters.

SETTING:

The delivery suite in the Department of Obstetrics and Gynaecology at the Süleyman Demirel University, Isparta, Turkey.

PARTICIPANTS:

Sixty-three singleton infants born at term with spontaneous or induced labour and initially normal fetal heart rate tracing.

METHODS:

After delivery, umbilical cord arterial and venous blood samples were collected for the determination of malondialdehyde concentrations. Oxygen saturation, pO2, pCO2, pH, and base excess were also measured.

MAIN OUTCOME MEASURES:

Umbilical cord arterial and venous blood gases and malondialdehyde levels.

RESULTS:

There was a significant correlation between umbilical arterial and venous levels of malondialdehyde and all acid-base parameters (P < 0.001). There were negative correlations between malondialdehyde levels and pH, pO2 and bicarbonate, while there was a positive correlation between malondialdehyde concentrations and pCO2. A positive correlation between malondialdehyde levels and base excess was present in the control group and total breech group (n = 35). The malondialdehyde levels in the total breech group, nonacidaemic breech group (n = 23) and the mildly acidaemic breech group (n = 12) were significantly higher than those in the control group (P < 0.0001). However, acid-base parameters in the nonacidaemic breech group were not statistically different from those in the control group.

CONCLUSION:

Lipid peroxidation products (malondialdehyde) existed to some extent in the umbilical cords of newborns with normal acid-base parameters in breech delivery. Our data support the contention that lipid peroxide may be a more sensitive measure for metabolic dysfunctions due to fetal hypoxia than acid-base balance.

• Authors: H Kaya, B Oral, R Dittrich, O Ozkaya
• Journal: BJOG : an international journal of obstetrics and gynaecology (BJOG) Vol. 107 Issue 8 Pg. 982-6 (Aug 2000) ISSN: 1470-0328 [Print] England
• PMID: 10955429 (Publication Type: Journal Article)

Chemical References

• Free Radicals
• Malondialdehyde

Topics

• Acid-Base Imbalance (metabolism)
• Adolescent
• Adult
• Breech Presentation
• Female
• Fetal Blood (chemistry)
• Fetal Hypoxia (complications)
• Free Radicals (blood)
• Humans
• Infant, Newborn
• Lipid Peroxidation (physiology)
• Malondialdehyde (blood)
• Oxidative Stress (physiology)
• Pregnancy
• Umbilical Arteries (metabolism)
• Umbilical Veins (metabolism)