[10-Hydroxycamptothecin induces apoptosis in human T24 urinary bladder cancer cells].

Abstract

OBJECTIVE:

To study the emechanisms of 10-Hydroxycamptothecine (HPT) inhibiting human urinary bladder cancer.

METHODS:

Using flow cytometry, electron microscopy and fluorescence microscopy, we studied the effects of HPT on human T24 urinary bladder cancer cells.

RESULTS:

HPT at 0.005 mg/L inhibited T24 bladder cancer cells by preventing the cells from S phase to G2/M phase and did not induce apoptosis. The apoptotic cells were induced by HPT at the concentration of 0.01-0.10 mg/L.

CONCLUSION:

HPT can inhibit human T24 urinary bladder cancer cells and induced apoptosis at some concentrations. The induction of apoptosis is a very important mechanism of 10-Hydroxycamptothecine to treat urinary bladder cancer cells.

• Authors: J Fan, X Tang, X Zhang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 78 Issue 4 Pg. 301-4 (Apr 1998) ISSN: 0376-2491 [Print] China
• PMID: 10923492 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• 10-hydroxycamptothecin
• Camptothecin

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis (drug effects)
• Camptothecin (analogs & derivatives, pharmacology)
• Cell Cycle (drug effects)
• Humans
• Tumor Cells, Cultured
• Urinary Bladder Neoplasms (pathology)