Abstract |
Cardiac diseases are well known among patients on maintenance hemodialysis (HD), and carnitine deficiency may be an important factor in cardiac morbidity. We studied the effects of low-dose L-carnitine treatment (500 mg/day) on chest symptoms ( dyspnea on exertion, chest pain, palpitation), cardiac function, and left ventricular (LV) mass in 9 HD patients with reduced ejection fraction (EF). After 6 months of L-carnitine treatment, most patients had at least some improvement in chest symptoms, while LVEF was increased and LV mass was decreased. Carnitine fractions increased and reached plateaus at 2-3 times the baseline levels. These results suggest that prolonged low-dose L-carnitine treatment can improve the cardiac morbidity by restoring decreased carnitine tissue levels and impaired oxidation of FFA.
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Authors | Y Matsumoto, M Sato, H Ohashi, H Araki, M Tadokoro, Y Osumi, H Ito, H Morita, I Amano |
Journal | American journal of nephrology
(Am J Nephrol)
2000 May-Jun
Vol. 20
Issue 3
Pg. 201-7
ISSN: 0250-8095 [Print] Switzerland |
PMID | 10878401
(Publication Type: Journal Article)
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Copyright | Copyright 2000 S. Karger AG, Basel |
Chemical References |
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Carnitine
(administration & dosage, blood, deficiency)
- Dietary Supplements
- Female
- Heart Function Tests
- Humans
- Hypertrophy, Left Ventricular
(drug therapy)
- Kidney Failure, Chronic
(therapy)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Renal Dialysis
- Stroke Volume
(drug effects)
- Treatment Outcome
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