Abstract | OBJECTIVE: To determine the extent of pre- and intraoperative hematogenic tumor cell dissemination in patients undergoing liver resection for metastatic colorectal cancer. SUMMARY BACKGROUND DATA: For patients with hepatic metastases of colorectal cancer, liver resection is the only potentially curative therapy. However, 38% to 53% of patients develop extrahepatic tumor recurrence, probably caused by tumor cells disseminated before or during surgery not detected by current staging systems. METHODS: RESULTS:
Tumor cells were detected in the blood samples of 26 of the 41 patients (63.4%) and in the bone marrow samples of 8 of the 30 patients (26.7%). Tumor cells were detected significantly more often during surgery than before or after surgery. Intraoperative tumor cell dissemination was detected in 41.7% of patients undergoing resection of two or more liver segments but only 14.3% of patients undergoing resection of one liver segment. Compared with resection of primary colorectal cancer, major liver resection carries an increased risk for intraoperative tumor cell dissemination. CONCLUSIONS:
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Authors | J Weitz, M Koch, P Kienle, A Schrödel, F Willeke, A Benner, T Lehnert, C Herfarth, M von Knebel Doeberitz |
Journal | Annals of surgery
(Ann Surg)
Vol. 232
Issue 1
Pg. 66-72
(Jul 2000)
ISSN: 0003-4932 [Print] United States |
PMID | 10862197
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Intermediate Filament Proteins
- KRT20 protein, human
- Keratin-20
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
- Bone Marrow
(pathology)
- Colorectal Neoplasms
(pathology)
- Female
- Hepatectomy
- Humans
- Intermediate Filament Proteins
- Intraoperative Period
- Keratin-20
- Liver Neoplasms
(pathology, secondary, surgery)
- Male
- Middle Aged
- Neoplastic Cells, Circulating
(pathology)
- Prospective Studies
- Reverse Transcriptase Polymerase Chain Reaction
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