Abstract | BACKGROUND: METHODS: Blood samples were obtained during surgery from 126 patients. Based on these samples, patients were placed into a high- antigen group, with a concentration above a selected cutoff value, or into a low- antigen group, with a tumor marker concentration below that same value. The blood samples obtained from peripheral veins were designated by the "p" prefix, and samples from drainage veins were designated by the "d." RESULTS: Serum d-SLX levels were significantly higher than p-SLX levels (P < .0001), although there was no difference between those of d-CA19-9 and p-CA19-9. Only 1 (3.6%) of 28 patients in the high d-CA19-9 group had a low p-CA19-9. In contrast, 6 (33.3%) of 18 patients in the high d-SLX group had low p-SLX levels (P = .0103). Correlations between pathological variables and either p-CA19-9 levels or d-CA19-9 levels were similar. However, both distant metastasis and venous invasion did prove to be independent variables related to d-SLX levels, as shown by logistic regression analysis. CONCLUSIONS: SLX may drain predominantly via the draining veins of colorectal tumors into portal circulation, whereas CA19-9 may drain via another route.
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Authors | T Nakagoe, T Sawai, T Tsuji, M Jibiki, M Ohbatake, A Nanashima, H Yamaguchi, T Yasutake, H Ayabe, Y Tagawa |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 7
Issue 4
Pg. 289-95
(May 2000)
ISSN: 1068-9265 [Print] United States |
PMID | 10819369
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Tumor-Associated, Carbohydrate
- CA-19-9 Antigen
- Gangliosides
- Oligosaccharides
- Sialyl Lewis X Antigen
- sialyl Le(a) ganglioside
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Topics |
- Aged
- Antigens, Tumor-Associated, Carbohydrate
(blood)
- CA-19-9 Antigen
(blood)
- Colorectal Neoplasms
(immunology)
- Female
- Gangliosides
(blood)
- Humans
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Oligosaccharides
(blood)
- Sialyl Lewis X Antigen
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