Abstract | BACKGROUND: METHODS: This prospective randomized trial was conducted to investigate the prevention of major operating site infections after nonlaparotomy surgery, with treatment regimens as follows: the first group of patients received 2 g of intravenous cefotiam dihydrochloride (CTM) on the induction of anesthesia, while the second group received 100 mg of oral cefpodoxime proxetil (CPDX- PR) twice daily, from day 0 to day 2. RESULTS: Nineteen of the 207 patients enrolled developed postoperative infections diagnosed by our simple criteria for postoperative infection. The frequency of febrile morbidity was not significantly less in patients who received CTM (9 cases; 8.6%) as compared with those in the CPDX-PR group (10 cases; 9.8%) (p = 0.56). CONCLUSION: The administration of oral CPDX-PR (100 mg, twice daily, for 3 days) appears to be a safe, cost-saving, convenient prophylaxis which reduces overall expense.
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Authors | H Hayashi, Y Yaginuma, T Yamashita, A Morizaki, T Ishiya, Y Katou, M Ishikawa |
Journal | Chemotherapy
(Chemotherapy)
2000 May-Jun
Vol. 46
Issue 3
Pg. 213-8
ISSN: 0009-3157 [Print] Switzerland |
PMID | 10765039
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2000 S. Karger AG, Basel. |
Chemical References |
- Cephalosporins
- Cefotiam
- Ceftizoxime
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Topics |
- Administration, Oral
- Adult
- Antibiotic Prophylaxis
- Cefotiam
(administration & dosage, economics, therapeutic use)
- Ceftizoxime
(administration & dosage, analogs & derivatives, economics, therapeutic use)
- Cephalosporins
(administration & dosage, economics, therapeutic use)
- Cost-Benefit Analysis
- Female
- Humans
- Hysterectomy
- Injections, Intravenous
- Laparoscopy
- Middle Aged
- Postoperative Complications
(microbiology, prevention & control)
- Prospective Studies
- Surgical Wound Infection
(microbiology, prevention & control)
- Cefpodoxime
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