Acellular pertussis vaccines.

Abstract

Although whole-cell pertussis vaccines have been highly effective in preventing whooping cough, their common and burdensome adverse reactions have spurred the development of safer alternatives. Seven acellular vaccines are licensed in one or more countries; four have been licensed thus far in the United States, and more may follow. Although the licensed acellular pertussis vaccines differ in their immunogenicity, adverse reactions, and efficacy, all are effective and, compared with whole-cell vaccine, are associated with markedly fewer and milder adverse reactions.

• Authors: M D Decker, K M Edwards
• Journal: Pediatric clinics of North America (Pediatr Clin North Am) Vol. 47 Issue 2 Pg. 309-35 (Apr 2000) ISSN: 0031-3955 [Print] United States
• PMID: 10761506 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Bacterial
• Diphtheria-Tetanus-Pertussis Vaccine
• Pertussis Vaccine

Topics

• Antibodies, Bacterial
• Child
• Clinical Trials as Topic
• Contraindications
• Corynebacterium diphtheriae (immunology)
• Diphtheria-Tetanus-Pertussis Vaccine (immunology)
• Humans
• Pertussis Vaccine (adverse effects)