Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS: The coronary patients had elevated ratios of squalene (p < 0.001), desmosterol (p = 0.005), campesterol (p = 0.028) and sitosterol (p = 0.022) to cholesterol, but had lower respective lathosterol value (p = 0.041) compared with the controls, despite similar serum cholesterol levels. Adjusted for age, body mass index, family history of CAD, smoking, hypertension, serum triglycerides, low-density lipoprotein ( LDL) and high-density lipoprotein ( HDL) cholesterol level and glycosylated hemoglobin A1c% (GHbA1c), the ratios of squalene (odds ratio, 1.36; 95% confidence interval, 1.17 to 1.57), lathosterol (0.98; 0.97 to 0.99), campesterol (1.01; 1.00 to 1.01) and sitosterol (1.01; 1.00 to 1.03) were significantly associated with the risk of CAD. In addition, family history of CAD and GHbA1c% were also independently related to the presence of CAD. CONCLUSIONS:
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Authors | R A Rajaratnam, H Gylling, T A Miettinen |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 35
Issue 5
Pg. 1185-91
(Apr 2000)
ISSN: 0735-1097 [Print] United States |
PMID | 10758959
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Glycated Hemoglobin A
- Phytosterols
- Sitosterols
- Desmosterol
- campesterol
- gamma-sitosterol
- Squalene
- lathosterol
- Cholesterol
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Topics |
- Case-Control Studies
- Cholesterol
(analogs & derivatives, blood, metabolism)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Coronary Disease
(diagnostic imaging, metabolism)
- Desmosterol
(blood)
- Fasting
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Middle Aged
- Phytosterols
- Postmenopause
(metabolism)
- Prevalence
- Radiography
- Reproducibility of Results
- Risk Factors
- Sensitivity and Specificity
- Sitosterols
(blood)
- Squalene
(blood)
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