[Evaluating signal intensity of movement-impaired myocardial segments in MR delayed images after administration of Gd-DTPA. Correlation of regional increase in contraction after revascularization].

Abstract

PURPOSE:

The aim of the study was to correlate delayed contrast enhancement of dysfunctional regions of the myocardium after injection of Gd-DTPA with the improvement of regional contractility 3 months after revascularization.

MATERIAL AND METHODS:

Eleven patients with coronary artery disease and wall motion abnormalities underwent MR imaging before and 3 months after revascularization therapy (PTCA or CABG). Short-axis images were acquired using a cine gradient echo sequence. After revascularization, a representative slice was analyzed 14 +/- 1 min after injection of 0.1 mmol/kg Gd-DTPA using a T1-weighted turbo fast low-angle shot sequence. Improved systolic wall thickening 3 months after revascularization served as criterion of viability and was correlated with delayed contrast enhancement patterns.

RESULTS:

After revascularization, 6 patients showed complete recovery of the dysfunctional area, 1 patient partial recovery, and 4 patients remained unchanged. All 4 patients with persisting wall motion abnormalities, 1/6 patients with recovery and the patient with partial recovery revealed a delayed enhancement.

CONCLUSIONS:

Three months after revascularization, delayed enhancement of dysfunctional myocardium is evident in patients without regional wall motion improvement, while the lack of delayed enhancement correlates with improvement of regional contractility.

• Authors: J Sandstede, C Lipke, M Beer, W Kenn, T Pabst, S Neubauer, D Hahn
• Journal: Der Radiologe (Radiologe) Vol. 40 Issue 2 Pg. 150-4 (Feb 2000) ISSN: 0033-832X [Print] Germany
• Vernacular Title: Signalintensitätsbeurteilung motilitätsgestörter Myokardareale in MR-Spätaufnahmen nach Gabe von Gd-DTPA. Korrelation zur regionalen Kontraktilitätszunahme nach Revaskularisierung.
• PMID: 10758629 (Publication Type: English Abstract, Journal Article)

Chemical References

• Contrast Media
• Gadolinium DTPA

Topics

• Adult
• Aged
• Contrast Media
• Diastole (physiology)
• Female
• Follow-Up Studies
• Gadolinium DTPA
• Humans
• Image Enhancement
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Myocardial Contraction (physiology)
• Myocardial Infarction (diagnosis, physiopathology, therapy)
• Myocardial Revascularization
• Myocardial Stunning (diagnosis, physiopathology)
• Sensitivity and Specificity
• Systole (physiology)
• Treatment Outcome
• Ventricular Dysfunction, Left (diagnosis, physiopathology)