Does endoscopic laser ablation of the prostate stand the test of time? Five-year results from a multicentre randomized controlled trial of endoscopic laser ablation against transurethral resection of the prostate.

Abstract

OBJECTIVE:

To determine the long-term objective and subjective outcome of patients with benign prostatic enlargement (BPE) treated by endoscopic laser ablation of the prostate (ELAP), as part of a multicentre randomized controlled trial of ELAP against TURP.

PATIENTS AND METHODS:

Initially, 151 patients with BPE were randomized to undergo either ELAP or TURP, starting in March 1992. ELAP was performed using the Urolasetrade mark fibre (Bard, Covington, GA, USA) in conjunction with a Nd:YAG laser source. All patients who had originally participated in the study were approached 5 years later to obtain a urological history, American Urological Association (AUA) symptom score and two measurements of urinary flow rate, with an ultrasonographic assessment of the postvoid residual urine volume (PVR).

RESULTS:

The mean duration of follow-up was 61 months; 109 patients were traced, comprising 69 who were alive and well, and had undergone no further bladder outlet surgery, 26 who had required revision surgery, 12 who were dead or terminally ill and three who had dementia. Both ELAP and TURP produced sustained improvements in mean AUA score, maximum flow rate and PVR, with respective values at 5 years of 6.3, 17.8 mL/s and 76 mL, and 6.5, 20.0 mL/s and 55 mL. Eighteen of 47 ELAP patients (38%) and eight of 51 (16%) TURP patients underwent revision surgery within the follow-up.

CONCLUSION:

ELAP and TURP produced similar subjective and objective outcomes at 5 years. The re-operation rate after ELAP was more than double that after TURP and suggests that ELAP should not be used routinely in the management of men with BPE.

• Authors: W J McAllister, M J Absalom, K Mir, S Shivde, K Anson, R S Kirby, W T Lawrence, P J Paterson, G M Watson, C G Fowler
• Journal: BJU international (BJU Int) Vol. 85 Issue 4 Pg. 437-9 (Mar 2000) ISSN: 1464-4096 [Print] England
• PMID: 10691822 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Topics

• Endoscopy (methods)
• Humans
• Laser Therapy (methods)
• Male
• Prostatic Neoplasms (surgery)
• Reoperation
• Time Factors
• Transurethral Resection of Prostate (methods)
• Treatment Outcome