[Poor prognosis of osteosarcoma of pelvis; 39 years of registration by the Netherlands Commission on Bone Tumors].

Abstract

OBJECTIVE:

To evaluate the results of treatment in patients with osteosarcoma of the pelvis.

DESIGN:

Retrospective.

PATIENTS AND METHODS:

Sixty-five patients with pelvic osteosarcoma registered in the files of the Netherlands Committee on Bone Tumours over 1957-1995 were reviewed. Complete information was obtained on 62 cases: 27 males and 35 females, median age was 31 years (range: 12-83). Distant metastases were present in 11 patients (stage IIIB; 18%), while 50 patients had stage IIB osteosarcoma (81%) and 1 patient stage IB osteosarcoma (2%). The results of treatment and survival were determined.

RESULTS:

Median survival was 14 months (2-177), the 5-year survival 15%. Distant metastases developed in 27 of 42 (64%) patients with curatively treated stage IIB osteosarcoma, with prolonged metastasis-free survival after chemotherapy treatment (p < 0.0012). Survival in patients with stage IIB pelvic osteosarcoma was better after surgical resection of the primary tumour than after no operation (p < 0.0054); (neo)adjuvant chemotherapy gave no longer survival than surgery alone (p < 0.083).

CONCLUSION:

The prognosis of pelvic osteosarcoma was poor, despite modern multimodality treatment regimens, including surgical resection and chemotherapy.

• Authors: S J Ham, H M Kroon, H Schraffordt Koops, H J Hoekstra
• Journal: Nederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 144 Issue 3 Pg. 121-5 (Jan 15 2000) ISSN: 0028-2162 [Print] Netherlands
• Vernacular Title: Slechte prognose van bekkenosteosarcoom; 39 jaar registratie door de Nederlandse Commissie voor Beentumoren.
• PMID: 10674118 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Bone Neoplasms (mortality, radiotherapy, surgery, therapy)
• Child
• Combined Modality Therapy
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Netherlands (epidemiology)
• Osteosarcoma (mortality, radiotherapy, secondary, surgery, therapy)
• Pelvic Bones (surgery)
• Prognosis
• Registries (statistics & numerical data)
• Retrospective Studies
• Survival Rate