Effect of cisapride on acid gastro-oesophageal reflux during treatment with caffeine.

Abstract

About 50% of preterm infants and neonates receiving methylxanthines for respiratory stimulation will develop a pathological gastro-oesophageal reflux (GOR) pattern. In the face of potential GOR-related complications the effect of a concomitant treatment with a prokinetic agent, such as cisapride, should be evaluated. In this study 32 formerly preterm infants were studied simultaneously by 24-hour oesophageal pH monitoring and cardio-respirogram before the presumed end of caffeine treatment. In 14 of these infants a reflux index (RI; percentage of recording time) of more than 4% could be detected (pH <4). Ten of them were treated orally with cisapride (0. 2 mg/kg t.i.d.). Data of pH monitoring, cardio-respirogram and caffeine serum concentrations were obtained before and 5 days after introducing cisapride. The RI and the frequency of GOR decreased significantly with cisapride. The steady-state serum concentrations of caffeine were not influenced by cisapride and the extent of periodic breathing remained unchanged. In conclusion, cisapride has a positive influence on GOR parameters during caffeine treatment without impairing the oral bioavailability or therapeutic effect of caffeine.

• Authors: H Kentrup, H J Baisch, G Kusenbach, G Heimann, H Skopnik
• Journal: Biology of the neonate (Biol Neonate) Vol. 77 Issue 2 Pg. 92-5 (Feb 2000) ISSN: 0006-3126 [Print] Switzerland
• PMID: 10657685 (Publication Type: Journal Article)
• Copyright: Copyright 2000 S. Karger AG, Basel

Chemical References

• Gastrointestinal Agents
• Caffeine
• Cisapride

Topics

• Caffeine (blood, therapeutic use)
• Cisapride (administration & dosage, adverse effects, therapeutic use)
• Gastroesophageal Reflux (drug therapy)
• Gastrointestinal Agents (administration & dosage, therapeutic use)
• Humans
• Hydrogen-Ion Concentration
• Infant, Newborn
• Infant, Premature, Diseases (drug therapy)