Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma.

Abstract	The presence and distribution of Epstein-Barr virus (EBV), as well as human herpesvirus-6 and-8 (HHV-6 and HHV-8) was investigated by polymerase chain reaction in 191 samples from a variety of lymphoproliferative disorders. HHV-6 DNA was detected in 18% (30 of 169) of non-HHV-8 related lymphoproliferative disorders, with the highest frequency in AIDS-related lymphomas (8 of 25, 32%). In contrast, HHV-6 DNA was present in less than 5% (1 of 22) of HHV-8 related lymphoproliferative disorders [21 primary effusion lymphomas (PEL), and 1 cases of Castleman disease]. As compared to HHV-6, EBV DNA was frequently detected in PEL (11 of 19 samples, 58%). This study suggests that transformation to PEL is not enhanced by HHV-6, furthermore HHV-6 and -8 may interfere with each other.
Authors	H Asou, T Tasaka, J W Said, M Daibata, N Kamada, H P Koeffler
Journal	Leukemia research (Leuk Res) Vol. 24 Issue 1 Pg. 59-61 (Jan 2000) ISSN: 0145-2126 [Print] England
PMID	10634647 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References	DNA, Viral
Topics	Castleman Disease (epidemiology, virology) Cell Transformation, Neoplastic Cell Transformation, Viral Comorbidity DNA, Viral (isolation & purification) Epstein-Barr Virus Infections (complications, epidemiology) Herpesviridae Infections (complications, epidemiology) Herpesvirus 4, Human (isolation & purification, pathogenicity) Herpesvirus 6, Human (isolation & purification, pathogenicity) Herpesvirus 8, Human (isolation & purification, pathogenicity) Humans Japan (epidemiology) Lymphoma, AIDS-Related (epidemiology, virology) Lymphoma, B-Cell (epidemiology, virology) Lymphoma, B-Cell, Marginal Zone (epidemiology, virology) Lymphoma, Non-Hodgkin (epidemiology, virology) Lymphoproliferative Disorders (epidemiology, virology) Polymerase Chain Reaction Prevalence Tumor Virus Infections (complications, epidemiology) Viral Interference

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