| Abstract | PURPOSE: Intravenous immunoglobulins (IVIg) therapy has been reported to be beneficial in a large number of autoantibody-mediated or self-reactive T cells-associated autoimmune diseases. Thus, the beneficial effect of IVIg is probably due to multiple distinct mechanisms. MAIN POINTS: The immunoregulatory effect of IVIg in autoimmune diseases is dependent on: interaction of the Fc portion of IVIg with Fc receptors on leucocyte surfaces; interaction of infused IgG with complement components; modulation of synthesis and release of cytokines produced by lymphocytes and monocytes: V region-dependent neutralization of circulating autoantibodies by infused IgG; selection of immune repertoires; modulation of cell proliferation, particularly through modulation of Fas-induced apoptosis; interaction of IVIg with numerous other molecules onto the surface of T and B cells. PERSPECTIVES: Better understanding of these mechanisms should allow a better definition of the spectrum of diseases likely to benefit from IVIg treatment. |
| Authors | L Mouthon, S Lacroix-Desmazes, A Pashov, S V Kaveri, M D Kazatchkine
(Affiliation: Inserm U430, Hôpital Broussais, Paris.)
|
| Journal | La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne
(Rev Med Interne)
Vol. 20 Suppl 4
Pg. 423s-430s
( 1999)
ISSN: 0248-8663 FRANCE |
| Vernacular Title | Effets immunomodulateurs des immunoglobulines intraveineuses au cours des maladies auto-immunes. |
| PMID | 10522317
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
- Autoantibodies
- Cytokines
- Immunoglobulins, Intravenous
- Receptors, Fc
|
| Topics |
- Apoptosis
(drug effects)
- Autoantibodies
(drug effects)
- Autoimmune Diseases
(immunology, therapy)
- Cytokines
(drug effects)
- Humans
- Immunoglobulins, Intravenous
(immunology, therapeutic use)
- Lymphocytes
(drug effects)
- Monocytes
(drug effects)
- Receptors, Fc
(drug effects)
- Treatment Outcome
|
