Autoantibodies to GM1b and GalNAc-GD1a: relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China.

IgG antibodies to the minor gangliosides GM1b and GalNAc-GD1a frequently are present in sera of Japanese patients with Guillain-Barré syndrome. The relationship between these autoantibodies and Campylobacter jejuni infection, the type of disease (acute motor axonal neuropathy [AMAN], or acute inflammatory demyelinating polyneuropathy [AIDP]) has yet to be established. Sera samples were obtained from 55 Chinese patients with clinically defined Guillain-Barré syndrome. An electrophysiology study showed nine AIDP, 28 had AMAN, and 18 unclassified. C. jejuni serology was positively correlated with anti-GM1b and anti-GalNAc-GD1a IgG antibodies (respective P values, 0.007 and 0.02). The frequencies of positive anti-GM1b and anti-GalNAc-GD1a serology were greater in AMAN (32 and 21%) than in AIDP (11 and 0%), but the differences were not significant. Infection by C. jejuni may induce IgG anti-GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation.
AuthorsN Yuki, T W Ho, Y Tagawa, M Koga, C Y Li, K Hirata, J W Griffin
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 164 Issue 2 Pg. 134-8 (Apr 1 1999) ISSN: 0022-510X [Print] NETHERLANDS
PMID10402024 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Autoantibodies
  • Gangliosides
  • G(M1) Ganglioside
  • IV(4)-galactosyl-N-acetylganglioside GD1a
  • Acute Disease
  • Adolescent
  • Adult
  • Autoantibodies (analysis)
  • Axons (pathology)
  • Campylobacter Infections (immunology)
  • Campylobacter jejuni
  • Child
  • Child, Preschool
  • China
  • Female
  • G(M1) Ganglioside (immunology)
  • Gangliosides (immunology)
  • Humans
  • Male
  • Middle Aged
  • Motor Neuron Disease (immunology, pathology)
  • Polyradiculoneuropathy (immunology)

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