[Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke].

Abstract

Semax is the first domestic nootropic drug of an unexhausted type from the group of neuropeptides. In experimental studies it showed angioprotective, antihypoxic and neurotrophic activity in the doses 100-150 micrograms/kg. A combined clinical-electrophysiologic study revealed its high efficiency in acute ischemic stroke. A clinical trial was performed of immunobiochemical mechanisms of neuroprotective properties of Semax in acute period of ischemic stroke. A retrospective comparative clinicoimmunobiochemical analysis provided objective data on the molecular level on activating influence of Semax on antiinflammatory postischemic reactions in the brain. Shifting neuromediatory balance toward a prevalence of the antiinflammatory agents (interleukin-10, tumor necrosis factor-alpha) over the factors maintaining the inflammation (interleukin-8, C-reactive protein).

• Authors: N F Miasoedova, V I Skvortsova, E L Nasonov, E Iu Zhuravleva, I A Grivennikov, E L Arsen'eva, I I Sukhanov
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 99 Issue 5 Pg. 15-9 ( 1999) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Izuchenie mekhanizmov neĭroprotektivnogo deĭstviia semaksa v ostrom periode ishemicheskogo insul'ta.
• PMID: 10358912 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Neuroprotective Agents
• Peptide Fragments
• Tumor Necrosis Factor-alpha
• Interleukin-10
• ACTH (4-7), Pro-Gly-Pro-
• Adrenocorticotropic Hormone
• C-Reactive Protein

Topics

• Acute Disease
• Adrenocorticotropic Hormone (analogs & derivatives, therapeutic use)
• Brain (blood supply, drug effects, immunology)
• Brain Ischemia (cerebrospinal fluid, drug therapy, immunology)
• C-Reactive Protein (cerebrospinal fluid, immunology)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Interleukin-10 (cerebrospinal fluid, immunology)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Peptide Fragments (therapeutic use)
• Retrospective Studies
• Time Factors
• Tumor Necrosis Factor-alpha (cerebrospinal fluid, immunology)