p53 expression as a prognostic determinant in resected distal bile duct carcinoma.

Abstract

AIMS:

To determine the incidence and prognostic value of p53 immunopositivity in resectable distal bile duct carcinoma (DBDC).

METHODS:

Forty-seven paraffin-embedded archival tumour samples of patients with DBDC, who underwent subtotal pancreatoduodenectomy from 1985 to 1996, were immunohistochemically examined for p53 positivity, using the anti-p53 antibody D07.

RESULTS:

Nineteen (40%) of the 47 tumours demonstrated positive (>30%) p53 protein immunostaining. Focally positive or negative staining was seen in the remaining 28 (60%) cases. Patients in this low p53 category survived significantly longer than those in the high p53 category, with median survival durations of 29 and 13 months respectively (P=0. 039). p53 positivity was independent of age, sex, tumour size, radicality of resection, histopathological grading, lymph-node status, perineural invasion and vasoinvasive growth.

CONCLUSIONS:

This study indicates that low (0-30%) p53 expression is a favourable prognostic factor in patients with resected DBDC.

• Authors: A M Rijken, G J Offerhaus, M M Polak, D J Gouma, T M van Gulik
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 25 Issue 3 Pg. 297-301 (Jun 1999) ISSN: 0748-7983 [Print] England
• PMID: 10336811 (Publication Type: Journal Article)
• Copyright: Copyright 1999 W.B. Saunders Company Ltd.

Chemical References

• Tumor Suppressor Protein p53

Topics

• Adult
• Aged
• Bile Duct Neoplasms (chemistry, pathology, surgery)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Pancreaticoduodenectomy
• Predictive Value of Tests
• Prognosis
• Tumor Suppressor Protein p53 (analysis)