Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: After cytomegalovirus immunoglobulin infusions the placental edema decreased and the infected fetus started to grow once again, showing at birth only hepatosplenomegaly associated with viruria and cytomegalovirus deoxyribonucleic acidemia. Moreover, cytomegalovirus immunoglobulin G avidity increased and cell-mediated immunity improved. The other twin, who had negative results of cytomegalovirus culture and deoxyribonucleic acid detection at birth, was found to have cytomegalovirus deoxyribonucleic acid in the urine after 1 week. From the age of 9 months, however, both twins had persistent negative results of cytomegalovirus deoxyribonucleic acid detection. CONCLUSION: Although large-scale studies are needed to establish the real efficacy and the best therapeutic regimen, cytomegalovirus immunoglobulin may be considered for treatment or prevention of fetal cytomegalovirus infection.
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Authors | G Nigro, R La Torre, M M Anceschi, M Mazzocco, E V Cosmi |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 180
Issue 5
Pg. 1222-6
(May 1999)
ISSN: 0002-9378 [Print] United States |
PMID | 10329881
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA, Viral
- Immunoglobulin G
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Topics |
- Adult
- Cytomegalovirus
(genetics, immunology)
- Cytomegalovirus Infections
(diagnostic imaging, immunology, therapy)
- DNA, Viral
(blood)
- Diseases in Twins
- Female
- Fetal Diseases
(diagnostic imaging, therapy, virology)
- Fetal Growth Retardation
(therapy, virology)
- Humans
- Immunity, Cellular
- Immunization, Passive
- Immunoglobulin G
(immunology)
- Male
- Pregnancy
- Pregnancy Complications, Infectious
(therapy, virology)
- Twins
- Ultrasonography, Prenatal
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