Abstract | INTRODUCTION: METHODS: RESULTS: At all doses of IFN-gamma and TNF-alpha, DHA was found to be inhibitory to NO production. CONCLUSIONS: DHA inhibits macrophage-stimulated NO production in response to IFN-gamma and TNF-alpha. As NO is thought to be important in several disease processes, DHA may be a useful agent in the treatment of conditions such as autoimmune disease.
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Authors | D R Jeyarajah, M Kielar, J Penfield, C Y Lu |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 83
Issue 2
Pg. 147-50
(May 15 1999)
ISSN: 0022-4804 [Print] United States |
PMID | 10329109
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 1999 Academic Press. |
Chemical References |
- Fish Oils
- Recombinant Proteins
- Serum Albumin
- Tumor Necrosis Factor-alpha
- Docosahexaenoic Acids
- Nitric Oxide
- Interferon-gamma
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Topics |
- Animals
- Cells, Cultured
- Docosahexaenoic Acids
(pharmacology)
- Fish Oils
- Humans
- Interferon-gamma
(pharmacology)
- Macrophages, Peritoneal
(drug effects, physiology)
- Mice
- Mice, Inbred C3H
- Nitric Oxide
(biosynthesis)
- Recombinant Proteins
(pharmacology)
- Serum Albumin
(pharmacokinetics)
- Tumor Necrosis Factor-alpha
(pharmacology)
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