Abstract | BACKGROUND: METHODS: Animals underwent pulmonary artery catheterization to measure pulmonary hemodynamics before and 8 weeks after an injection of monocrotaline pyrrole, 3 mg/kg (n = 8) or placebo (n = 8) (controls). Systolic function was assessed with load-insensitive means (preload-recruitable stroke work). Myocardial biopsy specimens were collected to analyze membrane alpha1- and beta-adrenergic receptor density and adenylate cyclase activity. RESULTS: Eight weeks after injection, significant increases in pulmonary hemodynamic indices were noted in monocrotaline-injected dogs. Significant increases in right ventricular preload-recruitable stroke work were also observed in these animals compared with controls and occurred in association with significant increases in right ventricular alpha1- and beta-adrenergic receptor density and isoproterenol hydrochloride-stimulated adenylate cyclase activity. No significant differences in basal adenylate cyclase activity in the right ventricle were noted between the two groups. CONCLUSIONS:
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Authors | E P Chen, S A Akhter, H B Bittner, W J Koch, R D Davis, P Van Trigt 3rd |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 67
Issue 4
Pg. 1053-8
(Apr 1999)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 10320250
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Receptors, Adrenergic, alpha
- Receptors, Adrenergic, beta
- monocrotaline pyrrole
- Monocrotaline
- Adenylyl Cyclases
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Topics |
- Adaptation, Physiological
- Adenylyl Cyclases
(metabolism)
- Animals
- Chronic Disease
- Dogs
- Hemodynamics
(physiology)
- Hypertension, Pulmonary
(chemically induced, physiopathology)
- Monocrotaline
(analogs & derivatives)
- Myocardium
(metabolism)
- Pulmonary Circulation
(physiology)
- Receptors, Adrenergic, alpha
(analysis)
- Receptors, Adrenergic, beta
(analysis)
- Stroke Volume
(physiology)
- Ventricular Function, Right
(physiology)
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