Abstract | BACKGROUND: OBJECTIVE: DESIGN: Long-Evans rats were fed a basal diet or a similar diet containing 0.5% AMPhe + 3.0% L-phenylalanine (AMPhe + Phe diet) from day 11 until day 20 of gestation in experiments to test various mixtures of LNAAs. Maternal weight gains and food intakes to day 20, fetal body and brain weights at day 20, and fetal brain and fetal and maternal plasma amino acid concentrations at day 20 were measured. RESULTS: Concentrations of phenylalanine and tyrosine in fetal brain and in maternal and fetal plasma were higher and fetal brain weights were lower in rats fed the AMPhe + Phe diet than in rats fed the basal diet. However, fetal brain growth was higher and concentrations of phenylalanine and tyrosine in fetal brain and in maternal and fetal plasma were lower in rats fed the AMPhe + Phe diet plus LNAAs than in rats fed the diet containing AMPhe + Phe alone. CONCLUSION: LNAA supplementation of the diet improved fetal amino acid profiles and alleviated most, but not all, of the depression in fetal brain growth observed in this model of maternal PKU.
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Authors | R E Austic, C L Su, B J Strupp, D A Levitsky |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 69
Issue 4
Pg. 687-96
(Apr 1999)
ISSN: 0002-9165 [Print] United States |
PMID | 10197570
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Amino Acids, Branched-Chain
- alpha-methylphenylalanine
- Phenylalanine
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Topics |
- Amino Acids, Branched-Chain
(administration & dosage, blood, pharmacology)
- Animals
- Body Weight
(drug effects)
- Brain
(embryology, growth & development)
- Brain Chemistry
- Diet
- Embryonic and Fetal Development
(drug effects)
- Female
- Maternal-Fetal Exchange
- Phenylalanine
(analogs & derivatives)
- Phenylketonurias
(chemically induced, metabolism)
- Pregnancy
- Pregnancy Complications
(chemically induced, metabolism)
- Rats
- Rats, Long-Evans
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