HLA-DR beta-Chains

Transmembrane proteins that form the beta subunits of the HLA-DR antigens. They are also referred to as the HLA-DR light chains.

Also Known As:

HLA Class II Histocompatibility Antigen, DR beta Chain; HLA-DR Light Chain; HLA-DR beta-Chain; HLA DR Light Chain; HLA DR beta; HLA DR beta Chain; Light Chain, HLA-DR; beta-Chain, HLA-DR; HLA-DR beta

Networked: 64 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Iwamoto, Sadahiko: 1 article (08/2020)
2.	Kawai, Yosuke: 1 article (08/2020)
3.	Khor, Seik-Soon: 1 article (08/2020)
4.	Kutsuwada, Yukinobu: 1 article (08/2020)
5.	Matsumoto, Ayumi: 1 article (08/2020)
6.	Miyashita, Hiroshi: 1 article (08/2020)
7.	Nagasaki, Masao: 1 article (08/2020)
8.	Nakayama, Kazuhiro: 1 article (08/2020)
9.	Tokunaga, Katsushi: 1 article (08/2020)
10.	Watanabe, Kazuhisa: 1 article (08/2020)

Related Diseases

1.	Rheumatoid Arthritis 06/01/1995 - "Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DR beta 1 molecule. " 08/01/1993 - "This study was performed to determine if an association exists between Chinese with rheumatoid arthritis and a particular HLA-DR beta or DQ beta subtype. " 02/01/1999 - "Genotyping for disease associated HLA DR beta 1 alleles and the need for early joint surgery in rheumatoid arthritis: a quantitative evaluation." 03/01/1998 - "[Molecular analysis of HLA-DR beta polymorphism in Han nationality patients with rheumatoid arthritis]." 06/01/1994 - "The inheritance of HLA-DR beta 1 and of female sex predispose to rheumatoid arthritis but the cause is unknown; it may be viral. "
2.	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 03/01/1994 - "Immunophenotype studies of mononuclear cells of the peripheral blood showed characteristic membranous phenotype for Mantle zone lymphoma in leukaemic phase: Smlg+ (lambda light chain); HLA-DR+; CD19+; CD22+; CD5+; CD10-; CD25-. "
3.	Autoimmune Hepatitis 09/01/1996 - "Recent studies of autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) have identified substitutions of specific amino acid residues in the HLA DR beta-polypeptide (AIH and PSC) and DP beta-polypeptide (PBC) which may determine susceptibility to and resistance from disease. "
4.	Hematologic Neoplasms (Hematological Malignancy) 03/01/2004 - "The 1D10 antigen is the target for Hu1D10 (apolizumab), a humanized HLA-DR beta-chain-specific antibody that is currently in clinical trials for hematologic malignancies. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2000 - "Dr. Levy updates the experience with rituximab targeting CD20 on B cell lymphomas and reviews the antibodies to CD3, CD22, CD33, CD52, HLA-DR beta chain and HLA-D currently in or proposed for clinical trials, including radiolabelled antibodies. "

Related Drugs and Biologics

1.	Amino Acids
2.	Peptides (Polypeptides)
3.	Antigens
4.	Oligonucleotide Probes
5.	Antibodies
6.	HLA-D Antigens
7.	Rituximab (Mabthera)
8.	apolizumab
9.	Epitopes
10.	HLA-DR Antigens (HLA-DR)

Related Therapies and Procedures

1.	Replacement Arthroplasty
2.	Transplantation
3.	Therapeutics