Abstract |
Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DR beta 1 molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis, Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DRB1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.
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Authors | E Zanelli, M A Gonzalez-Gay, C S David |
Journal | Immunology today
(Immunol Today)
Vol. 16
Issue 6
Pg. 274-8
(Jun 1995)
ISSN: 0167-5699 [Print] England |
PMID | 7544977
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Epitopes
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQB1 antigen
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- I-E-antigen
- Collagen
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Topics |
- Alleles
- Animals
- Antigen Presentation
- Arthritis
(chemically induced, genetics, immunology)
- Arthritis, Rheumatoid
(ethnology, genetics, immunology)
- Autoimmune Diseases
(ethnology, genetics, immunology)
- Collagen
(toxicity)
- Disease Models, Animal
- Disease Susceptibility
(ethnology, immunology)
- Diseases in Twins
- Epitopes
(immunology)
- Genetic Predisposition to Disease
- HLA-DQ Antigens
(genetics, immunology)
- HLA-DQ beta-Chains
- HLA-DR Antigens
(genetics, immunology)
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
(genetics, immunology)
- Humans
- Mice
- Mice, Transgenic
- Polymorphism, Genetic
- T-Lymphocyte Subsets
(immunology)
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