Ubiquitin-Protein Ligase Complexes

Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
Also Known As:
Complexes, Ubiquitin-Protein Ligase; Ligase Complexes, Ubiquitin-Protein; Ubiquitin Protein Ligase Complexes
Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results


1. Itashiki, Yasutaka: 1 article (07/2005)
2. Supriatno,: 1 article (07/2005)
3. Kawashima, Yuichiro: 1 article (07/2005)
4. Sato, Mitsunobu: 1 article (07/2005)
5. Harada, Koji: 1 article (07/2005)
6. Yoshida, Hideo: 1 article (07/2005)
7. Mestan, J: 1 article (04/2001)
8. Slingerland, J: 1 article (04/2001)
9. Gstaiger, M: 1 article (04/2001)
10. Jordan, R: 1 article (04/2001)

Related Diseases

1. Neoplasms (Cancer)

Related Drugs and Biologics

1. Ubiquitin
2. Cyclin-Dependent Kinase Inhibitor p27
3. S-Phase Kinase-Associated Proteins (Skp1 Protein)
4. Cyclins
5. Phosphotransferases (Kinase)