Postmenopausal Osteoporosis

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1916 relevant articles (198 outcomes, 348 trials/studies) found for this Disease

Description: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.

Also Known As:

Osteoporosis, Postmenopausal; Osteoporosis, Post-Menopausal; Bone Losses, Perimenopausal; Bone Losses, Postmenopausal; Osteoporoses, Post-Menopausal; Osteoporoses, Postmenopausal; Osteoporosis, Post Menopausal; Perimenopausal Bone Losses; Post-Menopausal Osteoporoses; Post-Menopausal Osteoporosis; Postmenopausal Bone Losses; Postmenopausal Osteoporoses; Bone Loss, Perimenopausal; Bone Loss, Postmenopausal; Perimenopausal Bone Loss; Postmenopausal Bone Loss

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 83

Bone Diseases: 2380

Metabolic Bone Diseases: 2312

Osteoporosis: 11587

Postmenopausal Osteoporosis: 1916

Related Diseases

1.	Osteoporosis
2.	Bone Resorption
3.	Hypercalcemia (Milk Alkali Syndrome)
4.	Metabolic Bone Diseases (Osteopenia)
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Delmas, Pierre D: 13 articles (06/2008 - 03/2003)
2.	Christiansen, C: 12 articles (05/2006 - 09/2000)
3.	Reginster, Jean-Yves: 11 articles (06/2008 - 01/2004)
4.	Adachi, J D: 8 articles (01/2006 - 01/2001)
5.	Reginster, J Y: 7 articles (11/2006 - 01/2001)
6.	Cranney, A: 7 articles (01/2006 - 01/2001)
7.	Delmas, P D: 6 articles (05/2006 - 01/2001)
8.	Wells, G: 6 articles (01/2006 - 01/2000)
9.	Cranney, Ann: 6 articles (01/2005 - 08/2002)
10.	Roux, C: 6 articles (12/2004 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Postmenopausal Osteoporosis:

1.	DiphosphonatesIBA 01/01/2006 - "Bisphosphonates have been shown to be highly effective in preventing and treating postmenopausal osteoporosis (PMO) and the associated risk of fracture" 10/01/2005 - "Bisphosphonates, with their proven efficacy and safety, are the most commonly prescribed treatment for women with postmenopausal osteoporosis; however, optimal efficacy is often not achieved due to poor patient adherence to medication" 06/01/2003 - "Bisphosphonates are highly effective in postmenopausal osteoporosis" 01/01/2006 - "Oral bisphosphonates have proven efficacy in postmenopausal osteoporosis in clinical trials, but in practice the therapeutic benefits are often compromised by patients' low adherence" 01/01/1997 - "OBJECTIVE: The bisphosphonates have proven efficacy in the management of post-menopausal osteoporosis" Order ALL the reference details at left...
2.	Estrogens (Estrogen)FDA Link 06/15/2001 - "Estrogens have been convincingly shown to be highly effective in preventing and reversing menopause-related conditions, such as hot flushes, urogenital complaints, and postmenopausal bone loss" 06/15/2004 - "CONCLUSION: Pulsed estrogen therapy was as effective in normalizing bone turnover and preventing postmenopausal bone loss as a reservoir patch." 10/01/2002 - "Estrogen therapy has been shown to be effective in preventing postmenopausal bone loss and maintaining bone mineral density" 01/01/2001 - "Estrogen has traditionally been the only agent effective for the prevention and treatment of post-menopausal osteoporosis" 07/01/1999 - "Estrogen proves effective in preventing early postmenopausal bone loss by markedly inhibiting bone turnover" Order ALL the reference details at left...
3.	Alendronate (Alendronate Sodium)FDA LinkGeneric 02/01/2004 - "Alendronate has been proven to be effective in the prevention and treatment of postmenopausal osteoporosis with the recommended daily dose of 10 mg. However, a constraining requirement for dosing limited its general acceptance in treatment" 12/01/1995 - "The authors observe a significant reduction in value of the Nordin's Index (a sensible test for the screening of the "fast-losers" patients) in 10 women with post-menopausal osteoporosis after therapy with alendronate 5 mg daily per os for six months" 04/01/1999 - "Sequential measurements of stature are also valuable, and both methodologies have been used in Phase III clinical trials to assess the efficacy of alendronate to treat postmenopausal osteoporosis" 12/21/1999 - "A residual effect was seen 2 years after alendronate therapy was stopped; however, continuous alendronate treatment was more effective in preventing postmenopausal bone loss than 2 years of alendronate followed by 2 years of placebo." 01/01/2002 - "OBJECTIVE: Alendronate (10 mg daily) has been shown in long term clinical trials to be an effective treatment for postmenopausal osteoporosis" Order ALL the reference details at left...
4.	ibandronic acid (Boniva)FDA Link 04/01/2008 - "This meticulous methodology provided a highly effective means of identifying vertebral fractures and recruiting the trial population in which to assess the efficacy of ibandronate in postmenopausal osteoporosis." 01/01/2005 - "These simple ibandronate regimens are expected to provide the optimal combination of efficacy, tolerability and patient convenience, leading to improved treatment adherence and thus, enhanced outcomes in postmenopausal osteoporosis." 08/01/2008 - "In conclusion, 150-mg monthly oral ibandronate is an effective and well-tolerated long-term treatment for postmenopausal osteoporosis, with consistent improvement in BMD and bone turnover during 3 years' continuous treatment." 03/01/2008 - "CONCLUSION: Ibandronate IV injections are an effective and well tolerated treatment for postmenopausal osteoporosis and provide a useful alternative to oral dosing." 04/01/2006 - "CONCLUSION: Once-monthly ibandronate is an effective and well-tolerated treatment option for postmenopausal osteoporosis." Order ALL the reference details at left...
5.	CalciumIBA 09/01/1988 - "These results support the concept that calcium supplementation is useful in the treatment of postmenopausal osteoporosis." 06/01/1985 - "These results support the concept that calcium supplementation is useful in the treatment of postmenopausal osteoporosis." 06/01/1984 - "These results support the concept that calcium supplementation is useful in the treatment of postmenopausal osteoporosis." 02/01/2006 - "Our study is the first to report that FLL can modulate bone turnover and calcium balance in OVX rats and it might be a potential candidate for prevention and treatment of postmenopausal osteoporosis." 05/01/2003 - "STUDY SELECTION AND DATA EXTRACTION: Experimental and observational studies of the use of calcium and antiresorptive therapies for the prevention and treatment of postmenopausal osteoporosis were selected" Order ALL the reference details at left...
6.	Calcitonin (Calcitonin, Eel)FDA Link 03/28/1981 - "Calcitonin may prove effective in the prevention of postmenopausal bone loss" 01/01/2000 - "Studies 4 and 5 assessed the efficacy of the combined therapy of HRT and calcitonin in the prevention of early postmenopausal bone loss" 07/01/1993 - "Ongoing studies are evaluating the efficacy of intranasal calcitonin and of biphosphonates for the prevention of postmenopausal osteoporosis" 01/01/2004 - "The European Union's regulatory authority, the Committee for Proprietary Medicinal Products (CPMP), has confirmed the efficacy of calcitonin formulations for the treatment of postmenopausal osteoporosis and other bone disorders" 10/01/1998 - "A total of 107 patients were included in the study to determine the effects of different doses of intranasal calcitonin on bone mineral density and fracture risk in postmenopausal osteoporosis" Order ALL the reference details at left...
7.	Etidronic Acid (HEDP)FDA LinkGeneric 08/01/1992 - "Intermittent cyclical therapy with etidronate has been shown to be effective for postmenopausal osteoporosis in two controlled studies" 05/01/2000 - "Cyclical etidronate has been shown to be effective in the treatment of established postmenopausal osteoporosis but less is known about its effects on early menopausal bone loss" 12/01/1997 - "CONCLUSIONS: Long-term cyclical etidronate is a safe, effective, and well-tolerated treatment for postmenopausal osteoporosis" 01/01/1991 - "Intermittent cyclic etidronate treatment may be effective in preventing bone loss and in decreasing the risk of trabecular plate perforation, and thereby maintaining the integrity of bone architecture, in postmenopausal osteoporosis.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1997 - "Long-term efficacy of cyclical etidronate therapy in postmenopausal osteoporosis." Order ALL the reference details at left...
8.	Estradiol (Estrace)FDA LinkGeneric 12/01/2002 - "CONCLUSION: A daily dose of estradiol gel, either 0.75 mg or 1.5 mg, is effective in preventing early postmenopausal bone loss and relieving menopausal symptoms" 05/01/1995 - "Although 17 beta-estradiol (E2) replacement therapy has been shown to be effective in treating postmenopausal osteoporosis, the underlying mechanism remains unclear" 01/01/1994 - "OBJECTIVE: To determine whether the lowest available dose of percutaneous implant, 25 mg estradiol (E2), is effective for the prevention of postmenopausal bone loss" 09/01/2000 - "CONCLUSION: These results demonstrate that estradiol therapy with 1 mg estradiol is fully protective against early postmenopausal bone loss." 07/01/2000 - "OBJECTIVE: The aim of this study was to evaluate the efficacy, safety, and tolerability of 2 years' application of an estradiol matrix transdermal system for the prevention of postmenopausal bone loss" Order ALL the reference details at left...
9.	risedronic acid (risedronate)FDA LinkGeneric 01/01/2008 - "INTRODUCTION: Risedronate has been shown to be effective in the treatment of postmenopausal osteoporosis when given orally in daily or weekly doses or on 2 consecutive days per month" 01/01/2003 - "Based on this analysis, risedronate is a cost-effective treatment for postmenopausal osteoporosis within the German health care system, offering benefits for osteoporotic patients and for budget decision-makers." 04/01/2002 - "CONCLUSIONS: Risedronate is an effective and safe option for the treatment of postmenopausal osteoporosis" 04/01/2002 - "OBJECTIVE: To evaluate current scientific literature regarding the efficacy of risedronate in the prevention of vertebral and nonvertebral fractures in women with postmenopausal osteoporosis" 01/01/2008 - "MATERIAL AND METHODS: The study group comprised 19 patients with postmenopausal osteoporosis, aged 49-66 years, and receiving risedronate therapy" Order ALL the reference details at left...
10.	strontium ranelate (protelos)IBA 02/01/2006 - "The antifracture efficacy of strontium ranelate, 2 g per day orally, in the treatment of postmenopausal osteoporosis has been investigated in a large-scale, international, multicenter, phase 3 program in which more than 7000 patients were recruited" 12/01/2006 - "Strontium ranelate: a novel treatment in postmenopausal osteoporosis." 01/01/2006 - "Strontium ranelate: a novel treatment for postmenopausal osteoporosis: a review of safety and efficacy." 03/01/2005 - "Strontium ranelate: a new treatment for postmenopausal osteoporosis with a dual mode of action." 01/01/2005 - "A new treatment for post-menopausal osteoporosis: strontium ranelate." Order ALL the reference details at left...

Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 02/01/2001 - "Hormone replacement therapy is effective for postmenopausal osteoporosis, but in Japan patient acceptance of HRT is still low, and thus gynecologists are required of more effort to get an informed consent of HRT from the patient" 06/01/2003 - "The menopause has a large effect on bone density, and hormone replacement therapy (HRT) has been shown to be an effective treatment for preventing postmenopausal bone loss" 07/01/2002 - "Hormone replacement therapy (HRT) has been shown to be effective prevention of postmenopausal bone loss" 05/01/2000 - "It provides a safe and effective therapeutic option for the prevention of postmenopausal osteoporosis in women who are unwilling or unable to tolerate hormone replacement therapy." 09/01/2002 - "Hormone Replacement Therapy (HRT) is recognized as a gold standard for postmenopausal osteoporosis" Order ALL the reference details at left...
2.	Estrogen Replacement Therapy 06/01/1997 - "Replacement estrogen therapy is of proven efficacy for the prevention and treatment of postmenopausal bone loss" 06/01/1991 - "Estrogen replacement therapy is effective in the prophylaxis of postmenopausal osteoporosis, and is the only therapy with well-proven antifracture efficacy" 01/01/2001 - "Although estrogen replacement therapy (ERT) has been established as an effective treatment for postmenopausal bone loss, the clinical features which predict the effects of ERT have not been well investigated in Japanese postmenopausal women" 02/01/1995 - "Estrogen replacement therapy is effective in the prevention of postmenopausal osteoporosis, and a direct action of 17-beta-estradiol (17 beta E2) on osteoblastic and osteoclastic cells has been demonstrated" 04/01/1996 - "Estrogen replacement is known to manifest bone protective effects in the treatment of postmenopausal osteoporosis" Order ALL the reference details at left...
3.	Transplants (Transplant) 09/01/2005 - "In conclusion, improvement in bone turnover, increase in BMD, and reduction in fracture rates have been described during alfacalcidol treatment in situations characterized by a high rate of bone loss, including CS-induced osteoporosis, early postmenopausal bone loss, and organ transplant" 11/01/1997 - "The newer pharmacologic agents, nasal spray calcitonin and alendronate, have shown promising results in postmenopausal osteoporosis, and their ease of administration and low incidence of side effects make them ideal for renal transplant patients." Order ALL the reference details at left...
4.	Exercise (Aerobic Exercise) 02/01/1994 - "To examine whether physical exercise is beneficial in preventing postmenopausal osteoporosis, we measured bone mineral density (BMD) in three distinct groups of healthy postmenopausal Japanese women aged 49-61 yrs: 11 volleyball players (V) and 5 joggers (J), and 9 controls (C) who had not been participating in regular physical activity" 11/01/2004 - "Physical exercise programs or guidelines aimed at the prophylaxis of postmenopausal osteoporosis that draw on research evidence supporting the benefit of encouraging physical exercise need yet to be put in place as a matter of urgency." 01/01/2002 - "Several meta-analyses confirm that physical exercise can slow down postmenopausal bone loss, but it is not clear whether physical exercise alone can increase bone mass" 06/01/1987 - "These results support the view that suitable physical exercise may be a valuable treatment for postmenopausal osteoporosis in human beings." 10/01/1984 - "Extension or isometric exercises seem to be more appropriate for patients with postmenopausal osteoporosis." Order ALL the reference details at left...
5.	Exercise Therapy (Therapy, Exercise) 09/01/2008 - "Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss" Order ALL the reference details at left...

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