Denervation

The resection or removal of the nerve to an organ or part.

Also Known As:

Laser Neurectomy; Neurectomy; Peripheral Neurectomy; Radiofrequency Neurotomy; Denervations; Laser Neurectomies; Neurectomies; Neurectomies, Laser; Neurectomies, Peripheral; Neurectomy, Laser; Neurectomy, Peripheral; Neurotomies, Radiofrequency; Neurotomy, Radiofrequency; Peripheral Neurectomies; Radiofrequency Neurotomies

Networked: 9272 relevant articles (663 outcomes, 1149 trials/studies)

Relationship Network

Therapy Context: Research Results

Operative Surgical Procedures: 35827
- Neurosurgical Procedures: 1624
  - Denervation: 9272

Experts

1.	Mahfoud, Felix: 132 articles (04/2024 - 05/2011)
2.	Böhm, Michael: 108 articles (04/2024 - 12/2010)
3.	Schmieder, Roland E: 75 articles (05/2024 - 12/2010)
4.	Schlaich, Markus P: 68 articles (04/2024 - 12/2009)
5.	Ewen, Sebastian: 45 articles (03/2024 - 01/2013)
6.	Azizi, Michel: 44 articles (05/2024 - 04/2012)
7.	Ukena, Christian: 43 articles (03/2024 - 05/2011)
8.	Kario, Kazuomi: 42 articles (02/2024 - 06/2013)
9.	Bohnen, Nicolaas I: 37 articles (12/2023 - 11/2003)
10.	Linz, Dominik: 37 articles (01/2022 - 07/2012)

Related Diseases

1.	Pain (Aches) 08/01/1985 - "In the first few days before denervation can develop, abnormalities of motor unit recruitment are most helpful in differentiating weakness due to impaired conduction as opposed to pain or voluntary lack of effort. " 01/01/2023 - "In addition, the feasibility of robot-assisted microsurgery has been proven for varicocelectomy and microsurgical denervation of the spermatic cord, with acceptable improvement in sperm parameters and pain, respectively. " 11/01/2020 - "Higher degrees of relief from cervical medial branch thermal radiofrequency neurotomy are more often achieved, to a statistically significant extent, if patients are selected on the basis of complete relief of index pain following comparative diagnostic blocks. " 01/01/2016 - "Endoscopic denervation of the medial branches of the dorsal rami supplying the FJ has recently been appraised as providing excellent intraoperative visualization and long term pain relief for these patients. " 04/01/2006 - "Complete wrist denervation resulted in subjective long-term improvement in two thirds and in a complete or marked pain relief in half of the patients. "
2.	Hypertension (High Blood Pressure) 01/01/2021 - "Of these, renal denervation is the most mature, and with a recent series of proof-of-concept trials demonstrating the safety and efficacy of radiofrequency and more recently ultrasound-based renal denervation, this technology is poised to become available as a viable treatment option for hypertension in the foreseeable future. " 02/01/2024 - "Although proven effective in some trials, controversial trials, such as the Controlled Trial of Renal Denervation for Resistant Hypertension (SYMPLICITY-HTN3), have demonstrated contradictory results for the effectiveness of RDN in resistant hypertension (HTN). " 05/01/2013 - "Experimental and clinical studies suggest that renal denervation therapy is an effective and safe treatment for patients with therapy-resistant hypertension leading to a reduction in blood pressure and in systemic and renal sympathetic nervous activation, which plays an important role in the development, progression and prognosis of arterial hypertension. " 02/01/2013 - "This case illustrates the feasibility and potential efficacy of catheter-based renal denervation in patients with a renal artery stent, an important finding as persistent hypertension is common in patients despite successful renal artery stenting and currently available trials examining renal denervation have excluded patients with prior renal artery stents." 03/03/2022 - "Finally, renal artery denervation is another procedure that has proven effective in the management of hypertension."
3.	Vertigo (Positional Vertigo) 01/01/1996 - "Transtemporal, supralabyrinthine vestibular neurectomy offers an effective cure for disabling vertigo while preserving hearing in Menière's disease. " 07/01/2008 - "The purpose of this study is to report the excellent efficacy of vertigo control, the good preservation of hearing, the rare complications and the simplicity of retrosigmoid vestibular neurectomy performed by an interdisciplinary team of neurosurgery and otorhinolaryngology experts of our teaching hospital. " 08/01/2022 - "After the vestibular neurectomy, all four patients presented a complete resolution of vertigo episodes and improved functional level. " 04/01/1994 - "The very small number of patients with disabling chronic paroxysmal positional vertigo (more than 1 year duration) can be effectively relieved of the positional vertigo (95%) by selective transection of the nerve supply to the posterior canal sense organ (singular neurectomy) through a tympanotomy approach using local anesthesia. " 09/01/1987 - "The RSG-IAC vestibular neurectomy is an important improvement in the evolution of vestibular neurectomy for the treatment of vertigo. "
4.	Atrophy 01/01/2001 - "The marked decrease of alpha2M we have detected in denervated muscle may be responsible, at least in part, for the proteolytic increase which is known to occur in skeletal muscle during denervation atrophy." 03/01/2017 - "In contrast to muscle changes after tendon release, denervation of the muscle led to a decrease in the pennation angle of lengthened muscle fibers, with a reduced mean cross-sectional area of pooled muscle fibers, a slow- to fast-type transformation, and an increase in the area percentage of hybrid fibers, leading to overall significantly greater atrophy of the corresponding muscle. " 01/15/2016 - "These quadriceps with PB, compared with the other 119 quadriceps without PB, showed a significantly greater association with muscle fiber denervation atrophy (5/5 versus 55/119; p=0.02, by two-tailed Fisher's exact test), for which aging is not confounding. " 11/01/1997 - "There was a significantly greater somal atrophy, loss of synaptic profiles, rough endoplasmic reticulum and polyribosomes compared to unilateral neurectomy. " 09/01/1982 - "Although both types atrophied following denervation, type I atrophied to a lesser extent than type II. Electrical stimulation was beneficial in retarding denervation atrophy for both types. "
5.	Low Back Pain (Lumbago) 07/04/2017 - "In 3 randomized clinical trials of participants with chronic low back pain originating in the facet joints, sacroiliac joints, or a combination of facet joints, sacroiliac joints, or intervertebral disks, radiofrequency denervation combined with a standardized exercise program resulted in either no improvement or no clinically important improvement in chronic low back pain compared with a standardized exercise program alone. " 01/01/2018 - "We studied the clinical and nerve pathologic features in 6 patients whose low back pain (LBP) was relieved by superior cluneal nerve (SCN) neurectomy to determine whether nerve compression was the mechanism underlying this type of LBP. " 09/01/2001 - "We conclude that there is moderate evidence that RF lumbar facet denervation is more effective for chronic low back pain than placebo. " 09/01/2016 - "Improved X-rays-guided radiofrequency thermocoagulation denervation is an effective, minimally invasive and convenient method for treating low back pain secondary to lumbar facet syndrome." 07/01/1998 - "Anterior interbody fusion, with the denervation of rami communicantes, may be effective for such low back pain."

Related Drugs and Biologics

1.	Antihypertensive Agents (Antihypertensives)
2.	salicylhydroxamic acid (SHAM)
3.	Dopamine (Intropin)
4.	Spironolactone (Aldactone)
5.	Steroids
6.	Adrenergic Agents (Adrenergic Drugs)
7.	Glucose (Dextrose)
8.	Botulinum Toxins (Botulinum Toxin)
9.	Adrenal Cortex Hormones (Corticosteroids)
10.	Epinephrine (Adrenaline)

Related Therapies and Procedures

1.	Catheters
2.	Therapeutics
3.	Arthrodesis
4.	Injections
5.	Nerve Block (Nerve Blocks)