Piwi-Interacting RNA

A class of small RNAs that are 24–31 nucleotides in length. They associate with the PIWI SUBFAMILY OF ARGONAUTE PROTEINS to form effector complexes known as piRNA-induced silencing complexes, which repress transposons via transcriptional or posttranscriptional mechanisms and maintain germline genome integrity. In addition to their role in transposon silencing, piRNAs in diverse organisms function in the regulation of cellular genes.

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Networked: 597 relevant articles (2 outcomes, 142 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mallick, Bibekanand: 11 articles (09/2023 - 02/2017)
2.	Weisz, Alessandro: 9 articles (01/2021 - 09/2014)
3.	Nassa, Giovanni: 8 articles (01/2021 - 09/2014)
4.	Rizzo, Francesca: 8 articles (01/2021 - 09/2014)
5.	Liu, Mo-Fang: 7 articles (03/2024 - 06/2015)
6.	Giurato, Giorgio: 7 articles (01/2021 - 09/2014)
7.	Tarallo, Roberta: 7 articles (01/2021 - 09/2014)
8.	Wang, Kai: 6 articles (01/2024 - 11/2020)
9.	van Rij, Ronald P: 6 articles (01/2023 - 01/2012)
10.	Siomi, Mikiko C: 6 articles (10/2022 - 11/2012)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2022 - "STATEMENT OF SIGNIFICANCE: The clinical translation of piRNAs for cancer diagnosis is hindered by efficacy of detection techniques due to tedious sample processing and costly instrumentation. " 04/21/2015 - "In this article, we review some of the key available evidence for the role of piRNAs and PIWI in human cancer and discuss ways in which our understanding of their functions may be improved. " 04/16/2024 - "While previous studies have explored the relationship between piRNA expression and cancer patient outcomes, a comprehensive investigation is still lacking. " 04/16/2024 - "This article examines the potential of using liquid biopsy with piRNAs to study cancer survival outcomes. " 01/01/2024 - "Recent studies have found that piRNAs are widely dysregulated in tumors and associated with tumor progression and a poor prognosis. "
2.	Carcinogenesis 01/01/2022 - "No animal model has been generated for DDX43; cellular studies have revealed that DDX43 has roles in piRNA amplification, tumorigenesis, RAS signaling, and innate immunity. " 12/01/2021 - "Numerous studies have revealed that piRNAs can play important roles in tumorigenesis via multiple biological regulatory mechanisms, including silencing transcriptional and posttranscriptional gene processes and accelerating multiprotein interactions. " 01/01/2020 - "This study aims to decipher the possible role of a repeat-derived piRNA, piR-39980 (identified from our previous piRNA profiling study in human NB cell lines) in tumorigenesis of NB cells. " 01/01/2018 - "Our study provides the first comprehensive piRNA landscape in these samples and a useful resource for further functional studies to decipher new mechanistic views of piRNA-mediated gene regulatory networks affecting ovarian oncogenesis. " 01/01/2016 - "Our results also reinforce the importance of fish as a suitable model system to study the role of piRNAs in tumorigenesis."
3.	Male Infertility (Male Sterility) 04/10/2024 - "This paper has reviewed recent studies on the mechanism of piRNA pathways mediating spermatogenesis and potential roles of piRNA disorders in the diagnosis and treatment of male infertility." 01/01/2023 - "Here, we will discuss the role of piRNA trimmers in piRNA biogenesis and function, describe consequences of piRNA trimmer mutations using mammalian models and human patients, and examine future avenues of piRNA trimming-related study for clinical advancements for male infertility." 04/15/2021 - "In the current study of Ni NPs-inducing toxicity, the expression profiles of piRNAs and their predicted target genes associated with male infertility, were obtained. " 08/01/2016 - "In this study, we aimed to explore the associations between genetic variants of important genes involved in piRNA biogenesis and male infertility with spermatogenic impairment. " 03/29/2024 - "These results show that AS of testis-specific genes can affect synapsis and the piRNA biosynthetic processes in dzo, which may be important factors associated with hybrid male sterility in dzo."
4.	Breast Neoplasms (Breast Cancer) 07/01/2013 - "The aim of this study was to investigate the expression of piRNAs in breast cancer. " 10/01/2022 - "This review aims to focus on the role of piRNAs in the initiation, progression, and the occurrence of breast cancer in order to understand its function and provide a better therapeutic strategy." 09/30/2020 - "Biopathological Significance of PIWI-piRNA Pathway Deregulation in Invasive Breast Carcinomas." 01/01/2020 - "scaRNA, piRNA) in human breast cancer. " 12/01/2019 - "We examined the top 20 highly expressed piRNAs based on the analysis of TCGA breast cancer data in two patient cohorts to test the roles of piRNAs in breast cancer. "
5.	Stomach Neoplasms (Stomach Cancer) 05/01/2019 - "The present study aimed to identify the piRNAs associated with human gastric cancers across the whole transcriptome. " 04/01/2016 - "In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer. " 11/03/2020 - "Correction for Shi et al., PIWIL1 promotes gastric cancer via a piRNA-independent mechanism." 03/19/2020 - "The impacts of genetic variants in piRNA genes and their influence in gastric cancer development remains elusive, highlighting the gap in piRNA regulatory mechanisms knowledge. " 03/19/2020 - "piRNAs in Gastric Cancer: A New Approach Towards Translational Research."

Related Drugs and Biologics

1.	Piwi-Interacting RNA
2.	MicroRNAs (MicroRNA)
3.	Biomarkers (Surrogate Marker)
4.	Proteins (Proteins, Gene)
5.	RNA (Ribonucleic Acid)
6.	Long Noncoding RNA
7.	Circular RNA
8.	Transfer RNA (tRNA)
9.	Small Untranslated RNA
10.	Elements

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Precision Medicine
4.	Nephrectomy
5.	Immunotherapy