Clear Cell Chondrosarcoma

A chondrosarcoma of adolescence to old age of the proximal EPIPHYSES of long bones. It has variably clear cytoplasm of the mostly neoplastic CHONDROCYTES with little intervening matrix.

Also Known As:

Networked: 27 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Chondrosarcoma
2.	Chondroblastoma
3.	Neoplasms (Cancer)
4.	Chondroma (Enchondroma)
5.	Mesenchymal Chondrosarcoma

Experts

1.	Athanasou, Nick: 1 article (01/2018)
2.	Brown, Jennifer M: 1 article (01/2018)
3.	Hassan, A Bass: 1 article (01/2018)
4.	Kudo, Akiro: 1 article (01/2018)
5.	Mantoku, Akiro: 1 article (01/2018)
6.	Oppermann, Udo: 1 article (01/2018)
7.	Sabokbar, Afsie: 1 article (01/2018)
8.	Casanova, José: 1 article (11/2017)
9.	Figueiredo, António: 1 article (11/2017)
10.	Fonseca, Rúben: 1 article (11/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Clear Cell Chondrosarcoma:

1.	VimentinIBA 02/01/2006 - "In our study of a series of clear cell chondrosarcomas (n = 15) and chondroblastomas (n = 35), S100, vimentin, aggrecan and collagen type II were detected by immunohistochemistry. " 05/01/1993 - "The observation of positive reaction to S-100 protein (S-100), vimentin (Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin in the cartilaginous tissue. " 07/01/1991 - "The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. "
2.	Collagen Type II (Type II Collagen)IBA 02/01/2006 - "We detected immunohistochemical evidence of type II collagen within both the extracellular matrix-rich (chondroid) and matrix-poor areas in all 15 cases of clear cell chondrosarcoma. " 02/01/2006 - "Therefore, our data show that in cases when clear cell chondrosarcoma and chondroblastoma pose a diagnostic challenge, the presence of type II collagen in the extracellular tumour matrix significantly supports the diagnosis of clear cell chondrosarcoma and aids in distinguishing it from chondroblastoma." 02/01/2006 - "Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma." 02/01/2006 - "In our study of a series of clear cell chondrosarcomas (n = 15) and chondroblastomas (n = 35), S100, vimentin, aggrecan and collagen type II were detected by immunohistochemistry. " 02/01/2013 - "We investigated the immunohistochemical expression profiles of cytokeratins (CAM5.2, AE1/AE3, CK7, CK8, CK18, and CK20), epithelial membrane antigen, SRY (sex-determining region Y)-box 9, type II collagen, runt-related transcription factor 2, and osteocalcin in clear cell chondrosarcoma and compared them with those in chondroblastoma, conventional chondrosarcoma, and osteosarcoma. "
3.	Aggrecans (Aggrecan)IBA 02/01/2006 - "Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma." 02/01/2006 - "In our study of a series of clear cell chondrosarcomas (n = 15) and chondroblastomas (n = 35), S100, vimentin, aggrecan and collagen type II were detected by immunohistochemistry. "
4.	Matrix Metalloproteinase 14 (MT1-MMP)IBA 10/01/1999 - "In this study, the expressions of MT1-MMP, MMP-2 and TIMP-2 were evaluated in 10 enchondromas, 34 conventional chondrosarcomas, 5 clear-cell chondrosarcomas, 7 mesenchymal chondrosarcomas and 8 dedifferentiated chondrosarcomas. "
5.	Tissue Inhibitor of Metalloproteinase-2IBA 10/01/1999 - "In this study, the expressions of MT1-MMP, MMP-2 and TIMP-2 were evaluated in 10 enchondromas, 34 conventional chondrosarcomas, 5 clear-cell chondrosarcomas, 7 mesenchymal chondrosarcomas and 8 dedifferentiated chondrosarcomas. "
6.	OsteonectinIBA 01/01/1991 - "Moreover, the study would call for further histogenetic evaluation of clear cell chondrosarcoma, since the pattern of osteonectin expression in that tumor seems to indicate an osteogenic rather than a chondrogenic origin." 01/01/1991 - "The present immunohistochemical study of osteonectin has distinctly separated clear cell chondrosarcoma from the other variants of chondrosarcoma, and aptly verified the specificity of this entity. " 01/01/1991 - "The three clear cell chondrosarcomas showed a strong immunoexpression of osteonectin in clear cell, chondroid and in osseous tumor areas. " 01/01/1991 - "Three cases of clear cell chondrosarcoma documented in the Bone Tumor Registry of Westphalia were examined for their patterns of osteonectin expression, and compared with other bone tumors of either osseous or cartilaginous origin, and with normal cartilage tissue. "
7.	S100 Proteins (S 100 Protein)IBA 01/01/1988 - "In contrast to the clear-cell chondrosarcoma we did not find S-100 protein in clear cells of our osteosarcomas. " 03/01/1985 - "The proliferating stromal cells in seven of the nine chondroblastomas stained for S-100 protein, as did the lacunar chondrocytes in all of the enchondromas and chondrosarcomas and rare stromal cells in the clear cell chondrosarcoma. " 03/01/1985 - "In an effort to investigate the utility of immunostaining for S-100 protein in the differential diagnosis of chondroblastoma, the expression of S-100 protein in nine chondroblastomas was compared with that in six giant cell tumors, six aneurysmal bone cysts, four giant cell reparative granulomas, six cases of fibrous dysplasia, two cases of osteitis fibrosa cystica, two nonossifying fibromas, and one clear cell chondrosarcoma. " 05/01/1993 - "The observation of positive reaction to S-100 protein (S-100), vimentin (Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin in the cartilaginous tissue. " 07/01/1991 - "The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. "
8.	GlycogenIBA 01/01/1991 - "Clear-cell chondrosarcomas show regions of cartilaginous tumour and areas of closely packed, glycogen-rich, large tumour cells with distinct boundaries. " 03/01/1985 - "In clear-cell chondrosarcoma, glycogen accumulation in the tumour cells was a prominent feature. " 11/01/1982 - "Two clear-cell chondrosarcomas localized in the proximal part of femur of a 46 years old man and a 36 year old woman had a lobular pattern and consisted of clear oval and polygonal cells with abundant glycogen. " 11/01/1990 - "Clear-cell chondrosarcoma is characterized by regions of chondroid matrix and areas of closely packed, glycogen-rich large tumor cells with distinct boundaries. "
9.	Wheat Germ AgglutininsIBA 05/01/1993 - "It was found for the first time that the clear cell chondrosarcoma was positive for wheat germ agglutinin (WGA) and concanavalin A (Con A). " 07/01/1991 - "It was found for the first time that the clear cell chondrosarcoma was positive for wheat germ agglutinin and concanavalin A. "
10.	Muramidase (Lysozyme)IBA 05/01/1993 - "The observation of positive reaction to S-100 protein (S-100), vimentin (Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin in the cartilaginous tissue. " 07/01/1991 - "The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/2007 - "Clinical studies have shown that development of second malignancies is an uncommon but real risk for chondrosarcoma survivors; the benefit of chemotherapy for dedifferentiated chondrosarcomas remains questionable; and late recurrences of clear cell chondrosarcomas emphasize the need for long-term follow up. "
2.	Therapeutics 08/01/2022 - "There are various treatment modalities available for clear cell chondrosarcoma, ranging from wide local resection and intralesional therapy to amputation. " 12/01/2005 - "Rare low-grade malignant cartilage tumors such as clear-cell chondrosarcoma need to be diagnosed in specialized centres to arrive at the correct therapy. "
3.	Hemipelvectomy 02/01/2005 - "One year later, there was recurrence of the femoral and intrapelvic masses and right hemipelvectomy was performed; the specimen was reported as clear cell chondrosarcoma. " 11/01/1996 - "Internal hemipelvectomy was performed and final pathology was most consistent with clear-cell chondrosarcoma, despite a negative S-100 immunohistochemical stain. "
4.	Surgical Amputation (Amputations) 08/01/2022 - "There are various treatment modalities available for clear cell chondrosarcoma, ranging from wide local resection and intralesional therapy to amputation. " 07/01/2005 - "A 67-year-old man presented with left lower cranial nerve paresis and dysfunction of the left cerebellar hemisphere 4 years after amputation of the left lower leg because of clear cell chondrosarcoma (CCC). "
5.	Hip Replacement Arthroplasty (Total Hip Replacement) 01/01/2015 - "Delayed diagnosis of clear cell chondrosarcoma after total hip replacement. "