Crush Injuries

Excessive compression of parts of the body that causes muscle swelling, fracture, and/or neurological disturbances in the affected areas. Crush injury with systemic manifestations is referred to as CRUSH SYNDROME.

Also Known As:

Networked: 1393 relevant articles (51 outcomes, 216 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteoporosis
2.	Wounds and Injuries (Trauma)
3.	Pain (Aches)
4.	Ischemia
5.	Edema (Dropsy)

Experts

1.	Pan, Hung-Chuan: 14 articles (01/2019 - 11/2007)
2.	Cheng, Fu-Chou: 13 articles (01/2019 - 11/2007)
3.	Chen, Chun-Jung: 10 articles (01/2019 - 11/2007)
4.	Elfar, John C: 9 articles (04/2022 - 08/2008)
5.	Sheu, Meei-Ling: 8 articles (01/2019 - 04/2009)
6.	Schwartz, M: 8 articles (07/2001 - 06/2000)
7.	Gu, Xiaosong: 7 articles (01/2021 - 05/2007)
8.	Foecking, Eileen M: 7 articles (01/2020 - 07/2008)
9.	Wang, Jian: 7 articles (01/2020 - 03/2010)
10.	Yang, Dar-Yu: 7 articles (01/2012 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Crush Injuries:

1.	Neuroprotective AgentsIBA 01/01/2023 - "Results: FB improved the recovery of neurobehavioral functions with a concomitant increase in axonal regeneration and neuroprotective effects on spinal cord neurons following crush injury. " 08/27/2020 - "This study confirmed the neuroprotective effects of NF on suppressing TRPV1 in a sciatic nerve crush injury. " 08/27/2020 - "The present study investigated the effects of NF on the control of TRPV1 in relation to neuroprotective effects of a sciatic nerve crush injury. " 03/03/2020 - "In this study, we sought to investigate the neuroprotective effect of a new dose regimen of EPO in severe sciatic nerve crush injury (SSCI). " 05/01/2009 - "This study assessed the neuroprotective effects of angelica injection in the rat sciatic nerve crush injury (SCI). "
2.	Peptides (Polypeptides)IBA 01/15/2010 - "The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury." 11/01/2020 - "Intraoperative single administration of neutrophil peptide 1 accelerates the early functional recovery of peripheral nerves after crush injury." 12/15/2014 - "The Achyranthes bidentata polypeptide k fraction enhances neuronal growth in vitro and promotes peripheral nerve regeneration after crush injury in vivo." 01/01/2008 - "It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex. " 03/01/2013 - "The protective effects of Achyranthes bidentata polypeptides on rat sciatic nerve crush injury causes modulation of neurotrophic factors."
3.	HydrogelsIBA 10/01/2023 - "The hydrogel is injected directly into the rat sciatic nerve-crush injury sites to investigate its capacity for nerve regeneration in vivo and is found to promote functional recovery and remyelination. " 01/01/2023 - "Thereafter, the QK-NLs@Gel hydrogel was directly injected into the site of peripheral nerve crush injury in a rat model, where it enhanced revascularization and promoted the M2-polarization of the macrophages, thus providing an optimized microenvironment for nerve regeneration. " 09/01/2022 - "When injected into the epineurium of crushed nerves, the composite hydrogel in the rat sciatic nerve crush injury model promoted nerve regeneration, functional recovery and vascularization. " 01/01/2021 - "To test their capacity to promote nerve regeneration in vivo, rat sciatic nerve crush injury was performed with MDP hydrogels injected directly into the injury sites. " 09/01/2018 - "For in vivo evaluation, the prepared hydrogel was administrated on the sciatic nerve crush injury in Wistar rats. "
4.	GAP-43 Protein (GAP 43 Protein)IBA 01/01/2023 - "Recently, we have shown that administration of Fraction B (FB) derived from catfish epidermal secretions accelerates healing of damaged nerve in a sciatic nerve crush injury, as it ameliorates the neurobehavioral deficits and enhances axonal regeneration, as well as protects spinal neurons and increases astrocytic activity and decreasing GAP-43 expression. " 01/01/1990 - "The intensity of the GAP-43 staining reaches a peak at 21 days and becomes undetectable nine weeks following crush injury and 36 weeks following sciatic nerve cut. " 01/01/1994 - "The magnitude and duration of increased GAP-43 mRNA expression were significantly greater following resection than crush injury. " 01/01/2019 - "Using a mouse model of sciatic nerve crush injury, we found that AA can significantly accelerate axonal regrowth in the early stage [3 days post-injury (dpi)], a finding that was revealed by immunostaining and Western blotting for antibodies against GAP-43 and SCG10. " 02/01/2015 - "(-)-Epigallocatechin-3-gallate modulates spinal cord neuronal degeneration by enhancing growth-associated protein 43, B-cell lymphoma 2, and decreasing B-cell lymphoma 2-associated x protein expression after sciatic nerve crush injury."
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/01/2018 - "This study reports on the first in vivo analysis of the expression of VEGF and VEGF family molecules in peripheral nerve degeneration and regeneration: for this purpose, different models of nerve lesion in rat were adopted, the median nerve crush injury and the median nerve transaction followed or not by end-to end microsurgical repair. " 03/01/2015 - "In the present study, we induced a selective crush injury to the left spinal roots C5 and C6 in 18 rats within 24 hours after birth and examined the effect of VEGF-gene therapy on nerve regeneration. " 07/01/2012 - "The expression of VEGF in dorsal root ganglia (DRGs), following crush injury to sciatic nerves, was studied by RT-PCR, immunohistochemistry. " 02/01/2012 - "Crush injury induced the expression of SDF-1α, with a peak of 10-14 days postinjury, and this increased expression of SDF-1α paralleled the deposition of CD34(+) cells, expression of VEGF, and expression of neurofilament. " 07/01/2009 - "The expression of VEGF in dorsal root ganglia (DRGs), following crush injury to sciatic nerves, was studied by reverse transcribed-polymerase chain reaction (RT-PCR), immunohistochemistry, electromicroscope, and electrophysiology. "
6.	Oxygen (Dioxygen)IBA 05/07/2018 - "The purpose of this study was to investigate the effects of oxygen ultra-fine bubbles (OUBs) on a sciatic nerve crush injury (SNC) model rats. " 09/01/2002 - "In this study, functional effects of hyperbaric oxygen treatment were studied in 2 series of rats after an injury to the sciatic nerve - a standardized crush injury and nerve transection and repair, respectively. " 05/07/2018 - "Administration of Oxygen Ultra-Fine Bubbles Improves Nerve Dysfunction in a Rat Sciatic Nerve Crush Injury Model." 12/01/2014 - "Given the fact that hyperbaric oxygen mechanisms of action target the pathophysiology of crush injuries it should be considered not only for the definition of viable tissue limits but also to enhance viability, even in the most serious situations. " 12/01/2014 - "Severe lower limb crush injury and the role of hyperbaric oxygen treatment: a case report."
7.	salicylhydroxamic acid (SHAM)IBA 01/01/2022 - "Thirty-six rats with sciatic nerve crush injury were divided into four groups that received US irradiation initiated 1, 7 or 14 d after injury, or sham stimulation for 4 wk. Motor function analysis was conducted weekly; however, there was no significant improvement attributed to US treatment. " 11/01/2000 - "A three-armed, blinded study including sham, control, and test groups was designed using the rat sciatic nerve crush injury model. " 01/01/2023 - "Male Wistar rats were randomly divided into 5 groups including control, sham, sciatic nerve crush injury (SNC), SNC + 20 mg/kg PB, and SNC + 40 mg/kg PB. " 12/01/2022 - "Our aim was to evaluate the long-term consequences in EF of bilateral nerve cavernous crush- injury (BNCI) in type 1 diabetic (DM) rats 30-male/12-week-old rats were divided into four groups: Sham, BNCI, DM, and BNCI + DM. " 11/01/2022 - "In the sham group, the sciatic nerve was exposed and restored to its place without inducing crush injury. "
8.	CalciumIBA 12/01/2007 - "Bovine aorta endothelial cells were cultured in vitro and the effects of serum from crush injury rats on cell apoptosis and intracellular calcium concentration ([Ca2+]i) were observed. " 01/01/1996 - "There was no relationship between serum OC levels and vertebral crush fractures, serum calcium concentrations or stage of MM, neither was there any relationship between initial serum OC levels and survival. " 08/01/1982 - "1. Calcium balances and formation rates of new bone measured with an improved tracer technique using 85Sr have been determined simultaneously in 21 patients with idiopathic osteoporosis and vertebral crush fractures. " 05/01/1992 - "Eighty-five patients, age 48 to 77 y with postmenopausal crush fracture osteoporosis, were investigated using a 7-d combined calcium balance and 47Ca tracer-kinetic turnover method taking the dermal calcium loss into account. " 01/01/1976 - "Rapid bone loss, high bone resorption and low calcium absorption are shown to be associated with poor oestrogen status, with crush fracture cases presenting an exaggerated view of the normal post-menopausal situation."
9.	Nerve Growth Factors (Neurotrophins)IBA 11/01/2007 - "The purpose of this study was to evaluate the effects of neurotrophic factors secreted by rat amniotic fluid mesenchymal stem cells on regeneration of sciatic nerve after crush injury. " 08/01/2002 - "In this study, we investigated the effects of T(MBP) treatment on the local immune response (by B cells and macrophages) and on the expression of neurotrophic factors after crush injury of the rat optic nerve. " 12/01/2015 - "Retraction: Enhancement of regeneration with glia cell line-derived neurotrophic factor-transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury." 04/01/2010 - "Enhancement of regeneration with glia cell line-derived neurotrophic factor-transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury." 10/01/1998 - "DRG neurons showed increased transport of all neurotrophins following crush injury to the sciatic nerve. "
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/01/2009 - "The aim of this study was to determine which compression injury was more painful and to compare behavior with expression of tumor necrosis factor (TNF)-alpha in DRG and apoptosis in the DRG following crush injury to the L5 nerve root or L5 spinal nerve. " 06/01/2009 - "Sciatic nerve crush injury induced elevation of tumor necrosis factor alpha (TNF-alpha) production and caused apoptosis. " 01/23/2004 - "Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice." 11/01/2000 - "We investigated the role of tumor necrosis factor (TNF)-alpha in the onset of neuronal and glial apoptosis after traumatic spinal cord crush injury in rats. " 08/01/1996 - "The potential benefits of tumor necrosis factor pretreatment in promoting motor functional recovery of peripheral nerve following low load crush injury were examined. "

Therapies and Procedures

1.	Low-Level Light Therapy (LLLT) 01/01/2020 - "Objective : The aim of the study was to perform a literature review to analyze the effect of photobiomodulation in experimental studies on peripheral nerve regeneration after sciatic nerve crush injury in rodents. " 04/01/2019 - "The aim of this study was to identify biochemical changes in sciatic nerve (SN) after crush injury and low-level laser therapy (LLLT) with 660 nm and 808 nm by Raman spectroscopy (RS) analysis. " 09/01/2022 - "Raman spectroscopy and sciatic functional index (SFI) after low-level laser therapy (LLLT) in a rat sciatic nerve crush injury model." 03/01/2020 - "Comparative effects of photobiomodulation therapy at wavelengths of 660 and 808 nm on regeneration of inferior alveolar nerve in rats following crush injury." 01/01/2020 - "Photobiomodulation in Sciatic Nerve Crush Injuries in Rodents: A Systematic Review of the Literature and Perspectives for Clinical Treatment."
2.	Injections 11/20/2020 - "The goal of this study was to investigate the effects of serial ultrasound-guided PRP injections of the appropriate concentration on the treatment of sciatic nerve crush injury, and explore the value of multimodality ultrasound techniques in evaluating the prognosis of crushed peripheral nerve. " 01/01/2020 - "The goal of this study was to evaluate the synergistic effects of serial ultrasound-guided PRP injections combined with low-dose USWs radiation on peripheral nerve regeneration in a crush injury model. " 03/01/2011 - "All mice underwent a unilateral facial nerve crush injury and received 7 doses of daily injections. " 09/01/2010 - "SD rats with T8 spinal cord crush injury were divided into 4 groups, namely group A (control) and groups B, C and D with injections of the MSCs, ChABC and MSCs+ChABC at the injury site, respectively. " 01/01/2017 - "Three groups of sheep underwent a nerve crush lesion: the first group (n = 3) was left to recover spontaneously (SR); the second group was administered saline injections (SI; n = 5) and a third group (n = 6) received PRGF injections and scaffolds immediately after the crush injury. "
3.	Lasers (Laser) 04/01/2019 - "The RS was effective in identifying the biochemical differences in the SN after the crush injury, and LASER 660 nm was more efficient than the LASER 808 nm in cell proliferation and repair of the injured SN." 01/01/1993 - "These data indicate that transcutaneous low power irradiation with the lasers and parameters involved in this study increased the rate of regeneration of rat facial nerve following crush injury." 03/01/2013 - "Twenty-five rats were used, divided into three groups: 1) intact nerve, no treatment; 2) crushed nerve, no treatment; 3) crush injury, laser irradiation applied on the medullary region corresponding to the roots of the sciatic nerve and subsequently on the course of the damaged nerve. " 03/01/2013 - "To investigate the influence of low intensity laser irradiation on the regeneration of the fibular nerve of rats after crush injury. " 01/01/2013 - "Controlled crush injury of the right common fibular nerve, immediately followed by increasing doses (G1: no irradiation; G2: simulated; G3: 5 J/cm(2); G4: 10 J/cm(2); G5: 20 J/cm(2)) laser irradiation directly on the lesion site for 21 consecutive days. "
4.	Resuscitation 02/01/2022 - "Pretreatment with a selective β1-blocker combined with fluid resuscitation significantly improved the survival rates of the rats with lethal crush injury. " 10/01/2018 - "Rats (n = 6) were anesthetized, hemorrhaged 20% of their blood volume, and subjected to a femur fracture and crush injuries to the small intestine, liver, and limb skeletal muscle without resuscitation. " 12/01/2006 - "We conclude that prophylactic combination of rhsTM administration and volume resuscitation may be an effective therapy for severe crush injury." 09/01/2023 - "In this article, we detail the extrication and review the treatment guidelines for crush injuries that focus on aggressive fluid resuscitation prior to and during extrication and medication administration only if hyperkalemia presents. " 06/01/2023 - "Of children survivors under the rubble, renal replacement treatment (hemodialysis) was required for only four, seven required amputation, and 12 needed only fluid resuscitation for crush injury. "
5.	Fasciotomy 09/01/2019 - "One point was assigned for each of the following injury characteristics: patient age >40, fasciotomy needed, bony fixation required, bony defect present, revascularization required, crush injury mechanism, degloving or avulsion injury present, and a soft tissue defect >50 cm2. " 01/01/2013 - "The patient underwent successful fasciotomy and K-wire stabilization of the thumb and was ultimately discharged with good function on day 4. Patient B suffered a crush injury of the right hand and presented with diffuse swelling associated with median nerve paresthesia. " 05/01/2003 - "Fasciotomy in crush injury resulting from prolonged pressure in an earthquake in Turkey." 02/09/1998 - "The crush injuries are treated conservatively without fasciotomy, despite high or increasing intracompartmental pressure. " 10/01/1987 - "The author concurs with the prevailing opinion that fasciotomy plays an important role in the successful management of crush injury. "