beta-Arrestin 1

A beta-arrestin that functions in the down-regulation of signaling by G-PROTEIN-COUPLED RECEPTORS. It is also a major regulator of INSULIN signaling via the ERK 1-2 PATHWAY, and many other signaling processes, especially in NEURONS and LEUKOCYTES.

Also Known As:

Networked: 103 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Hui: 4 articles (07/2017 - 09/2010)
2.	Yin, Deling: 4 articles (07/2017 - 09/2010)
3.	Pei, Gang: 4 articles (01/2017 - 08/2007)
4.	Luker, Gary D: 3 articles (01/2022 - 03/2012)
5.	Luker, Kathryn E: 3 articles (01/2022 - 03/2012)
6.	Caudle, Yi: 3 articles (07/2017 - 08/2014)
7.	Stuart, Charles: 3 articles (07/2017 - 08/2014)
8.	Liu, Chang: 3 articles (12/2013 - 08/2007)
9.	Yang, Hui: 2 articles (11/2022 - 01/2015)
10.	Jiang, Jie: 2 articles (12/2021 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 06/16/2023 - "In conclusion, the preferential activation of the β-arrestin 2 pathway by UNC9994 improves DRD2-mediated antiproliferative effects in PRL-PitNETs, suggesting a new pharmacological approach for resistant or poorly responsive tumors." 01/01/2023 - "β-arrestin 2 (ARRB2) is functionally implicated in cancer progression via various signaling pathways. " 08/11/2022 - "The downregulation of β-arrestin 2 directly enhanced the malignancy of GBM and abrogated the effects of BCAS1-SV1 on GBM cells. " 01/01/2017 - "Here, we compared the abilities of recombinant rhLH and rhCG to elicit cAMP, β-arrestin 2 activation, and steroidogenesis in HEK293 cells and mouse Leydig tumor cells (mLTC-1). " 01/01/2015 - "MTS assay revealed that silencing of β-arrestin 2 increased the sensitivity to anti-cancer drugs to some extent. "
2.	Seizures (Absence Seizure) 01/01/2022 - "This finding led us to hypothesize that perhaps β-arrestin 1 is protective against, whereas β-arrestin 2 is detrimental for δOR-agonist-induced seizures. "
3.	Respiratory Insufficiency (Respiratory Failure) 01/01/2021 - "ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression." 10/01/2021 - "Evaluation of G protein bias and β-arrestin 2 signaling in opioid-induced respiratory depression." 01/01/2021 - "To verify this important result that motivated the 'biased agonist' approach, we re-examined breathing in ß-arrestin 2-deficient mice and instead find no connection between ß-arrestin 2 and opioid respiratory depression. " 01/01/2021 - "We have investigated the potential acute desensitizing role of the β arrestin 2 (β-arr2) pathway on the ventilatory depression produced by levels of fentanyl ranging from analgesic to life-threatening (0.1 to 60 mg/kg ip) in control and β-arr2-deficient nonsedated mice. " 01/01/2021 - "This rationale stems from a study suggesting that MOR-induced ß-arrestin 2 dependent signaling is responsible for opioid respiratory depression, whereas adenylyl cyclase inhibition produces analgesia. "
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2013 - "Here we report that β-arrestin 2 expression is elevated in two independent cohorts of individuals with Alzheimer's disease. " 01/01/2013 - "Collectively, these studies identify β-arrestin 2 as a new therapeutic target for reducing amyloid pathology and GPCR dysfunction in Alzheimer's disease." 05/01/2014 - "Emerging evidence indicates that β-arrestin 2, an important regulator of G protein coupled receptors, is involved in the pathogenesis of Alzheimer's disease (AD). " 01/01/2013 - "β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease." 01/01/2023 - "The cytoplasmic multifunctional adaptor protein β-arrestin 2 (Arrb2) is involved in the occurrence of various nervous system diseases, such as Alzheimer's disease and Parkinson's disease. "
5.	Carcinogenesis 12/01/2021 - "Our previous study indicated that ARBB1 (arrestin beta 1) promotes hepatocellular carcinogenesis (HCC). " 01/01/2020 - "For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional scaffold protein regulating signal transduction and internalization of activated G protein-coupled receptors (GPCRs), has been considered with rising interest for carcinogenesis. "

Related Drugs and Biologics

1.	Arrestin
2.	Cyclin D3
3.	Cabergoline
4.	Everolimus
5.	Opioid Analgesics (Opioids)
6.	Proteins (Proteins, Gene)
7.	Amyloid (Amyloid Fibrils)
8.	Adenylyl Cyclases (Adenylyl Cyclase)
9.	Dual Specificity Phosphatase 1
10.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)

Related Therapies and Procedures

1.	Analgesia
2.	Electroacupuncture
3.	Punctures
4.	Ligation
5.	Laparotomy