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2- tert- butyl- 4- chloro- 5- (6- (4- fluorobutoxy)pyridin- 3- ylmethoxy)- 2H- pyridazin- 3- one

a PET probe for mitochondrial complex I

Also Known As:

18F-BCPP-BF; 2-tert-butyl-4-chloro-5-(6-(4-18F-fluorobutoxy)pyridin-3-ylmethoxy)-2H-pyridazin-3-one

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 2-tert-butyl-4-chloro-5-(6-(4-fluorobutoxy)pyridin-3-ylmethoxy)-2H-pyridazin-3-one: 3
  - Pyridazines: 11
    - 2-tert-butyl-4-chloro-5-(6-(4-fluorobutoxy)pyridin-3-ylmethoxy)-2H-pyridazin-3-one: 3

Experts

1.	Ohba, Hiroyuki: 2 articles (01/2020 - 07/2018)
2.	Tsukada, Hideo: 2 articles (01/2020 - 07/2018)
3.	Haruyama, Waka: 1 article (01/2020)
4.	Kitayama, Tetsuya: 1 article (01/2020)
5.	Prasad, Pottumarthi V: 1 article (01/2020)
6.	Saeki, Satoshi: 1 article (01/2020)
7.	Shimada, Takashi: 1 article (01/2020)
8.	Srivastava, Anand: 1 article (01/2020)
9.	Tanaka, Kayoko: 1 article (01/2020)
10.	Ube, Yuko: 1 article (01/2020)

Related Diseases

1.	Kidney Diseases (Kidney Disease) 01/01/2020 - "The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases." 01/01/2020 - "Here, 18F-BCPP-BF positron emission tomography was applied to three mechanistic kidney disease models in rats: kidney ischemia-reperfusion, 5/6 nephrectomy and anti-glomerular basement membrane glomerulonephritis. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 07/16/2018 - "Sensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with 18F-BCPP-BF."
3.	Ischemia 01/01/2020 - "In rats with ischemia-reperfusion, a slight decrease in the kidney uptake of 18F-BCPP-BF was accompanied by morphological abnormality of the mitochondria in the proximal tubular cells after three hours of reperfusion, when the kidney function was slightly declined. " 01/01/2020 - "Here, 18F-BCPP-BF positron emission tomography was applied to three mechanistic kidney disease models in rats: kidney ischemia-reperfusion, 5/6 nephrectomy and anti-glomerular basement membrane glomerulonephritis. "
4.	Glomerulonephritis 01/01/2020 - "In 5/6 nephrectomy and rats with anti-glomerular basement membrane glomerulonephritis, the kidney uptake of 18F-BCPP-BF cumulatively decreased with impairment of the kidney function, which was accompanied by a reduction of mitochondrial protein and a pathological tubulointerstitial exacerbation rather than glomerular injury. " 01/01/2020 - "Here, 18F-BCPP-BF positron emission tomography was applied to three mechanistic kidney disease models in rats: kidney ischemia-reperfusion, 5/6 nephrectomy and anti-glomerular basement membrane glomerulonephritis. "

Related Drugs and Biologics

1.	Mitochondrial Proteins (Mitochondrial Protein)

Related Therapies and Procedures

1.	Nephrectomy