HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

AZD9272

an mGluR5 antagonist

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        AZD9272: 2
  - Pyridines: 88
    - AZD9272: 2

Experts

1.	Arakawa, Ryosuke: 1 article (01/2020)
2.	Cselényi, Zsolt: 1 article (01/2020)
3.	Elmore, Charles S: 1 article (01/2020)
4.	Farde, Lars: 1 article (01/2020)
5.	Halldin, Christer: 1 article (01/2020)
6.	Johnström, Peter: 1 article (01/2020)
7.	Kingston, Lee: 1 article (01/2020)
8.	Moein, Mohammad Mahdi: 1 article (01/2020)
9.	Nag, Sangram: 1 article (01/2020)
10.	Stepanov, Vladimir: 1 article (01/2020)

Related Diseases

1.	Pain (Aches) 11/01/2013 - "This study aimed to investigate the effect of a single dose of the mGluR5-antagonist AZD9272 on electrically induced pain, central sensitization and axon reflex flare. " 11/01/2013 - "Single doses of the centrally acting mGluR5-antagonist AZD9272 did not reduce C-fibre evoked pain, central sensitization or flare reaction." 11/01/2013 - "The plasma levels of AZD9272 were maximal during the pain measurements and corresponded to >50% brain mGluR5 receptor occupancy. " 11/01/2013 - "No significant differences were found between AZD9272 and placebo regarding any of the AUC0-100 min variables for pain NRS, hyperalgesia area, allodynia area, flare area or flare intensity. "
2.	Psychotic Disorders (Schizoaffective Disorder) 01/01/2020 - "The findings are consistent with the hypothesis that both fenobam and AZD9272 bind to the MAO-B, which may be of relevance for understanding the mechanism of the psychosis-like adverse events reported for these compounds. " 01/01/2020 - "The metabotropic glutamate receptor 5 (mGluR5) ligands fenobam and AZD9272 have been reported to induce psychosis-like adverse events and to bind at unknown, non-GluR5-related, sites. "
3.	Hyperalgesia 11/01/2013 - "No significant differences were found between AZD9272 and placebo regarding any of the AUC0-100 min variables for pain NRS, hyperalgesia area, allodynia area, flare area or flare intensity. "

Related Drugs and Biologics

1.	Metabotropic Glutamate 5 Receptor
2.	Monoamine Oxidase (MAO)
3.	Ligands
4.	fenobam