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BIIB042

a salicylaldehyde and a gamma-secretase modulator; structure in first source

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aldehydes: 2153
  - BIIB042: 1

Experts

1.	Arastu, Mahin F: 1 article (04/2016)
2.	Brennan, Melanie S: 1 article (04/2016)
3.	Bussiere, Thierry: 1 article (04/2016)
4.	Chollate, Sowmya: 1 article (04/2016)
5.	Dunah, Anthone W: 1 article (04/2016)
6.	Dunstan, Robert W: 1 article (04/2016)
7.	Fahrer, Diana: 1 article (04/2016)
8.	Jung, Mi-Young: 1 article (04/2016)
9.	Kumaravel, Gnanasambandam: 1 article (04/2016)
10.	Moore Arnold, H: 1 article (04/2016)

Related Diseases

1.

Alzheimer Disease (Alzheimer's Disease)

04/01/2016 - "The pharmacodynamic effects of lowering Aβ42 in the central nervous system coupled with demonstrated efficacy in reducing plaque pathology suggests modulation of γ-secretase, with molecules like BIIB042, is a compelling therapeutic approach for the treatment of Alzheimer's disease. "
04/01/2016 - "BIIB042 reduced Aβ42 levels and Aβ plaque burden in Tg2576 mice, which overexpress human amyloid precursor protein and serve as a model system for Alzheimer's disease. "
04/01/2016 - "BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease."

Related Drugs and Biologics

1.	Amyloid Precursor Protein Secretases (beta-Secretase)
2.	Protein Isoforms (Isoforms)
3.	Proteins (Proteins, Gene)
4.	Amyloid (Amyloid Fibrils)