Acquired Protein C Deficiency

01/01/1997 - "To treat patients with hereditary and acquired protein C deficiency would require a greater amount of Protein C than that available from human plasma. "
06/01/2008 - "Human protein C concentrates for replacement therapy in congenital and acquired protein C deficiency."
04/01/2017 - "In the presence of activated protein C, no hypercoagulability was observed, adding to the current evidence that acquired protein C deficiency plays a key role in the coagulation imbalance."
05/01/2004 - "The Protein C concentrate is presently utilized as a therapy for patients with a congenital deficiency of protein C and several papers in the literature support the efficacy of protein C concentrate in the treatment of children with meningococcus septicemia, with the aim of correcting the acquired protein C deficiency often seen in septic conditions and shown to be strongly correlated to a higher morbidity and mortality. "
02/01/1993 - "Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: treatment with protein C concentrate."

01/01/2014 - "The mechanism is thought to be due to protein C deficiency acquired after initial exposure to warfarin. "
12/01/2003 - "Because warfarin anticoagulation induces acquired protein C deficiency, thereby exacerbating the prothrombotic state of type II HIT, warfarin should be withheld until platelet counts increase to more than 100,000/microL and type II HIT is clearly resolving. "
02/01/2003 - "This is the second reported case of warfarin necrosis associated with acquired protein C deficiency."
02/01/2003 - "Warfarin-induced skin necrosis associated with acquired protein C deficiency."
11/01/1997 - "This syndrome is characterised clinically by necrosis complicating deep venous thrombosis in the absence of large-vessel arterial occlusion, and appears to result from acquired protein C deficiency during warfarin therapy for deep vein thrombosis and HIT. "

10/01/1992 - "During the meningococcaemia, an initial mild and transient acquired protein C deficiency was seen but no protein S deficiency was observed despite consumption of the latter protein. "
06/01/2010 - "Acquired protein C deficiency may be caused by increased consumption (e.g., asphyxia, overt DIC, severe infection without overt DIC, acute VTE) or by decreased synthesis of the active carboxylated protein (e.g. "

09/01/2001 - "Extensive coumarin-induced skin necrosis in a patient with acquired protein C deficiency."
01/01/1997 - "These findings suggest that the pathology of coumarin necrosis is mediated via tumour necrosis factor alpha-associated inflammatory events, after activation of the coagulation pathway due to an inherited or transiently induced, acquired protein C-deficiency. "

01/01/1987 - "Finally, the clinical implications of a hereditary and acquired protein C deficiency, of a diminished protein S level and a lowered inhibitor of the activated protein C are discussed. "

10/01/1991 - "Acquired protein C deficiency can be observed in the course of purpura fulminans, disseminated intravascular coagulation, hepatic failure or in the presence of antiphospholipid antibodies. "

08/01/2002 - "Plasminogen activator inhibitor also prevented a switch from the procoagulant to the profibrinolytic state in lethal dengue hemorrhagic fever, which was further enhanced by an acquired protein C deficiency. "

01/01/1992 - "Several antineoplastic agents have been reported to decrease the production of protein C in the liver by impairing either the absorption or metabolism of vitamin K, leading to acquired protein C deficiency. "

11/01/2000 - "We report a case of stroke in a child with acquired protein C deficiency receiving valproic acid (VPA). "

01/01/1999 - "This syndrome occurs when acquired protein C deficiency during warfarin treatment of HIT and deep venous thrombosis leads to the inability to regulate thrombin generation in the microvasculature. "

06/01/2008 - "Human protein C concentrates for replacement therapy in congenital and acquired protein C deficiency."
05/01/2004 - "The Protein C concentrate is presently utilized as a therapy for patients with a congenital deficiency of protein C and several papers in the literature support the efficacy of protein C concentrate in the treatment of children with meningococcus septicemia, with the aim of correcting the acquired protein C deficiency often seen in septic conditions and shown to be strongly correlated to a higher morbidity and mortality. "
11/01/1997 - "This syndrome is characterised clinically by necrosis complicating deep venous thrombosis in the absence of large-vessel arterial occlusion, and appears to result from acquired protein C deficiency during warfarin therapy for deep vein thrombosis and HIT. "
06/01/1993 - "We have used a highly purified protein C concentrate to treat a patient with acquired protein C deficiency who developed skin necrosis during the initial phase of oral anticoagulant therapy. "

12/01/2014 - "Acquired protein C deficiency possibly precipitated acute retinal vein occlusion during laser therapy in this infant. "

09/01/2001 - "The presence and severity of acquired protein C deficiency were associated with poor clinical outcome, including lower survival rate, higher incidence of shock, and fewer ICU-free and ventilator-free days. "

11/29/1997 - "Severe acquired protein-C deficiency in meningococcaemia is usually associated with substantial mortality: in survivors, skin grafts, amputation, and end-organ failure are not uncommon. "