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1,2- diacetoxy- 3,14- dihydro- 3,3,14- trimethyl- 6- methoxy- 7H- benz(b)pyrano(3,2- d)acridin- 7- one

an alkylating antineoplastic agent

Also Known As:

S 23906; S-23906; S23906

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Acridones: 26
    - Acronine: 26
      - 1,2-diacetoxy-3,14-dihydro-3,3,14-trimethyl-6-methoxy-7H-benz(b)pyrano(3,2-d)acridin-7-one: 3
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Acridones: 26
        Acronine: 26
        1,2-diacetoxy-3,14-dihydro-3,3,14-trimethyl-6-methoxy-7H-benz(b)pyrano(3,2-d)acridin-7-one: 3

Experts

1.	Escargueil, Alexandre E: 3 articles (01/2015 - 08/2010)
2.	Henriques, João A P: 3 articles (01/2015 - 08/2010)
3.	Larsen, Annette K: 3 articles (01/2015 - 08/2010)
4.	Rocca, Céline J: 3 articles (01/2015 - 08/2010)
5.	Soares, Daniele G: 3 articles (01/2015 - 08/2010)
6.	Bouzid, Hana: 1 article (01/2015)
7.	Battistella, Aude: 1 article (07/2011)
8.	Matuo, Renata: 1 article (07/2011)
9.	Guérin, Eric: 1 article (08/2010)
10.	Ouadrani, Karima El: 1 article (08/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Tumors with deficiencies for proteins involved in HR, and BRCA2 in particular, may thus show increased sensitivity to S23906, thereby providing a rationale for patient selection in clinical trials." 01/01/2015 - "S23906 is an acronycine derivative that shows strong activity toward solid tumors in experimental models. "
2.	Carcinoma (Carcinomatosis) 08/01/2010 - "The pharmacological relevance of these findings was confirmed by the characterization of KB carcinoma cells with acquired S23906 resistance. "
3.	Ataxia Telangiectasia (Louis Bar Syndrome) 07/01/2011 - "In contrast, neither MRN (Mre11-Rad50-Nbs1) nor ATM (ataxia-telangiectasia mutated), contributes to the initial response to S23906. " 07/01/2011 - "Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphotransferases (Kinase)
3.	Alkylating Agents
4.	Acronine (Acronycine)