guttiferone A

12/01/2018 - "Guttiferone-A and its derivatives were combined with fluconazole through the checkerboard method and tested against Candida spp. The results obtained, especially the Fractional Inhibitory Concentration Index (FICI) determined to the combinations, suggests promising results on the treatment of Candida infections, principally for species that present resistance or low antifungal susceptibility. "

11/01/2017 - "In the present study a plant-derived compound, guttiferone- A, was evaluated for its anticancer activity against MCF-7 breast cancer cell line. "
11/01/2017 - "In vitro antitumor activity of guttiferone-A in human breast cancer cells is mediated via apoptosis, mitochondrial mediated oxidative stress and reactive oxygen species production."

11/01/2017 - "Taken together, we conclude that guttiferone- A is a potential anticancer molecule and may prove to be a lead molecule in cancer drug discovery."
11/01/2017 - "Additionally, guttiferone-A also induced apoptosis in MCF-7 cancer cells in a dose-dependent manner. "
11/01/2017 - "It was observed that guttiferone-A reduced the cell viability of MCF-7 cancer cells in a dose-dependent manner. "
06/15/2011 - "The anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: ensuing energetic and oxidative stress implications."
06/15/2011 - "Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with cytotoxic action in vitro and anti-tumor action in rodent models. "

12/01/2018 - "These results suggest the possibility of combined administration with reduction of doses and side effects of drugs conventionally used against Candida spp. and the promising therapeutic action of Guttiferone-A."

12/01/2012 - "We previously demonstrated a powerful iron-chelating action of Guttiferone-A (GA), a naturally occurring polyphenol, on oxidative stress injuries initiated by iron overload. "