HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

GDP 366

an antineoplastic agent; structure in first source

Also Known As:

GDP-366; GDP366

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - GDP 366: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        GDP 366: 2
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - GDP 366: 2

Experts

1.	Carlos, Jorge Antonio Elias Godoy: 1 article (01/2021)
2.	Costa-Lotufo, Leticia Veras: 1 article (01/2021)
3.	Leitão, Andrei: 1 article (01/2021)
4.	Lima, Keli: 1 article (01/2021)
5.	Machado-Neto, João Agostinho: 1 article (01/2021)
6.	Ding, Ke: 1 article (04/2010)
7.	Jin, Yanli: 1 article (04/2010)
8.	Lu, Zhongzheng: 1 article (04/2010)
9.	Pan, Jingxuan: 1 article (04/2010)
10.	Shi, Xianping: 1 article (04/2010)

Related Diseases

1.	Leukemia 01/01/2021 - "This study identified structural GDP366 analogs and the cellular and molecular mechanisms underlying their suppressive effects on acute leukemia cellular models. " 01/01/2021 - "These results indicated that GDP366 and AD80 reduced the PI3K/STMN1 axis and had cytotoxic effects in acute leukemia cellular models. " 01/01/2021 - "In acute leukemia cells, GDP366 and AD80 reduced cell viability and autonomous clonal growth in a dose- and/or time-dependent manner (p < 0.05) and induced apoptosis and cell cycle arrest (p < 0.05). "
2.	Neoplasms (Cancer) 04/15/2010 - "GDP366 significantly inhibited the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. " 04/15/2010 - "GDP366 induced polyploidy in multiple types of cancer cell lines. " 01/01/2021 - "GDP366 has been described as a STMN1 and survivin inhibitor in solid tumors. " 04/15/2010 - "GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells."
3.	Chromosomal Instability (Chromosome Stability) 04/15/2010 - "GDP366 increased chromosomal instability, and induced cellular senescence by inhibiting telomerase activity. "
4.	Polyploidy 04/15/2010 - "GDP366 induced polyploidy in multiple types of cancer cell lines. "

Related Drugs and Biologics

1.	Survivin
2.	Telomerase (Telomerase Reverse Transcriptase)