13-acetoxyrolandrolide

from Rolandra fruticosa; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Kinghorn, A Douglas: 2 articles (07/2014 - 04/2010)
2.	Pan, Li: 2 articles (07/2014 - 04/2010)
3.	Swanson, Steven M: 2 articles (07/2014 - 04/2010)
4.	de Blanco, Esperanza J Carcache: 2 articles (07/2014 - 04/2010)
5.	Acuña, Ulyana Muñoz: 1 article (07/2014)
6.	Matthew, Susan: 1 article (07/2014)
7.	Chai, Hee-Byung: 1 article (04/2010)
8.	Farnsworth, Norman R: 1 article (04/2010)
9.	Kardono, Leonardus B S: 1 article (04/2010)
10.	Lantvit, Daniel D: 1 article (04/2010)

1.	Colonic Neoplasms (Colon Cancer) 07/01/2014 - "After 24 h of treatment with 13-acetoxyrolandrolide, the mitochondrial transmembrane potential was depolarized in human colon cancer (HT-29) cells. " 04/01/2010 - "Cytotoxicity-guided fractionation of a methanol extract of the leaves and twigs of Rolandra fruticosa using the HT-29 human colon cancer cell line led to the isolation of seven sesquiterpene lactones, including the hitherto unknown isorolandrolide, 13-methoxyisorolandrolide (1), and bourbonenolide, 2alpha,13-diacetoxy-4alpha-hydroxy-8alpha-isobutyroyloxybourbonen-12,6alpha-olide (2), as well as five known compounds, 13-acetoxyrolandrolide (3), 8-desacyl-13-acetoxyrolandrolide-8-O-tiglate (4), 2-epi-glaucolide E (5), 2alpha,13-diacetoxy-4alpha-hydroxy-8alpha-methacryloyloxybourbonen-12,6alpha-olide (6), and 2alpha,13-diacetoxy-4alpha-hydroxy-8alpha-tigloyloxybourbonen-12,6alpha-olide (7). "
2.	Neoplasms (Cancer) 07/01/2014 - "Cell flow cytometry showed that 13-acetoxyrolandrolide induced cell cycle arrest at G1 , indicating that the treated cells had undergone caspase-3-mediated apoptosis, indicating negative effects on cancer cell proliferation. "