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3- bromo- 10- difluoromethyl- 9H- imidazo(1,5- a)(1,2,4)triazolo(1,5- d)(1,4)benzodiazepine

structure in first source

Also Known As:

RO4938581

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 3-bromo-10-difluoromethyl-9H-imidazo(1,5-a)(1,2,4)triazolo(1,5-d)(1,4)benzodiazepine: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        3-bromo-10-difluoromethyl-9H-imidazo(1,5-a)(1,2,4)triazolo(1,5-d)(1,4)benzodiazepine: 5

Experts

1.	Bundgaard, Christoffer: 2 articles (05/2013 - 06/2012)
2.	Redrobe, John P: 2 articles (05/2013 - 06/2012)
3.	Gasser, Rodolfo: 2 articles (02/2013 - 10/2009)
4.	Knoflach, Frédéric: 2 articles (02/2013 - 10/2009)
5.	Thomas, Andrew W: 2 articles (02/2013 - 10/2009)
6.	Ahmed, Md M: 1 article (01/2018)
7.	Block, A: 1 article (01/2018)
8.	Gardiner, K J: 1 article (01/2018)
9.	Hernandez, M-C: 1 article (01/2018)
10.	Martinez-Cué, C: 1 article (01/2018)

Related Diseases

1.	Cognitive Dysfunction 06/01/2012 - "The objectives of this study were to investigate the potential of RO4938581, a negative modulator of GABA(A) α5 receptors, and to attenuate cognitive impairments induced following sub-chronic (sub-PCP) and early postnatal PCP (neo-PCP) administration in the novel object recognition (NOR) and intra-extradimensional shift (ID/ED) paradigms in rats. " 05/01/2013 - "RO4938581, an imidazo-triazolo-benzodiazepine, is a novel GABAAα5 negative modulator recently pursued for the treatment of cognitive dysfunctions. " 10/15/2009 - "The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction." 02/27/2013 - "These data demonstrate that reducing GABAergic inhibition with RO4938581 can reverse functional and neuromorphological deficits of TS mice by facilitating brain plasticity and support the potential therapeutic use of selective GABA(A) α5 NAMs to treat cognitive dysfunction in DS."
2.	Down Syndrome (Down's Syndrome) 01/01/2018 - "The GABAAα5-selective Modulator, RO4938581, Rescues Protein Anomalies in the Ts65Dn Mouse Model of Down Syndrome."

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Therapeutic Uses
3.	Proteins (Proteins, Gene)
4.	Benzodiazepines
5.	RO 4882224