|1.||Wiman, K G: 4 articles (12/2010 - 02/2007)|
|2.||Selivanova, Galina: 2 articles (05/2011 - 05/2005)|
|3.||Rökaeus, N: 2 articles (12/2010 - 02/2007)|
|4.||Shen, J: 2 articles (12/2010 - 11/2008)|
|5.||Bykov, V J N: 2 articles (12/2010 - 03/2010)|
|6.||Chibon, Frédéric: 1 article (01/2015)|
|7.||Italiano, Antoine: 1 article (01/2015)|
|8.||Neuville, Agnes: 1 article (01/2015)|
|9.||Grellety, Thomas: 1 article (01/2015)|
|10.||Lagarde, Pauline: 1 article (01/2015)|
|1.||Sarcoma (Soft Tissue Sarcoma)
11/01/2013 - "Our study for the first time shows antimyeloma activity of PRIMA-1(Met) and provides the rationale for its clinical evaluation in patients with multiple myeloma, including the high-risk group with p53 mutation/deletion."
11/01/2013 - "Results of our study showed that PRIMA-1(Met) decreased the viability of multiple myeloma cells irrespective of p53 status, with limited cytotoxicity toward normal hematopoietic cells. "
11/01/2013 - "Treatment of multiple myeloma cells with PRIMA-1(Met) resulted in induction of apoptosis, inhibition of colony formation, and migration. "
11/01/2013 - "In this study, we evaluated antitumor effect of PRIMA-1(Met) alone or its combination with current antimyeloma agents in multiple myeloma cell lines, patient samples, and a mouse xenograft model. "
11/01/2013 - "Importantly, PRIMA-1(Met) delayed tumor growth and prolonged survival of mice bearing multiple myeloma tumor. "
01/01/2015 - "PRIMA-1(MET) anti-tumor activity in STS partly results from off-target effects involving ROS toxicity and do not deserve further development as a TP53-targeted therapy in this setting."
11/12/2013 - "PRIMA-1(Met), also known as APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. "
05/01/2011 - "Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations. "
05/01/2011 - "PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. "
03/04/2010 - "The low molecular weight compound PRIMA-1(MET) reactivates mutant p53 and triggers mutant p53-dependent apoptosis in human tumor cells. "
|4.||Prostatic Neoplasms (Prostate Cancer)
|1.||Small Interfering RNA (siRNA)
|2.||Proteins (Proteins, Gene)
|6.||2,2- bis(hydroxymethyl)- 1- azabicyclo(2,2,2,)octan- 3- one
|1.||Heterologous Transplantation (Xenotransplantation)