piperlongumine

06/01/2024 - "Therefore, to improve its therapeutic efficacy, we developed piperlongumine-loaded PLGA-based smart nanoparticles (smart PL-NPs) that can rapidly release PL in an acidic environment of cancer cells and provide optimum drug concentrations to overcome chemoresistance. "
04/04/2022 - "Taken together, this study elucidates the molecular mechanism of the antitumor capacity of piperlongumine by targeting TXNRD1 and reveals the potential possibility of inhibiting TXNRD1 to strengthen cancer cells' ferroptosis."
01/01/2019 - "In the present study, we reported the natural compound, piperlongumine, has a profound anti-tumor effect on NSCLC via regulation of glycolysis. "
10/05/2017 - "In the present study, the antimetastatic effect of piperlongumine (PL) was assessed in human cancer cells. "
09/29/2016 - "Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. "

04/01/2015 - "In the present study, we observed that human breast cancer MCF-7 cells are sensitive to piperlongumine-induced apoptosis relative to human MCF-10A breast epithelial cells. "
10/31/2022 - "These results support the potential applicability of piplartine-loaded NE-HA for intraductal treatment of breast cancer."
10/31/2022 - "In 1-methyl-1-nitrosourea -induced breast cancer models, intraductal administration of piplartine-loaded NE-HA inhibited breast tumor development and histological alterations. "
01/01/2017 - "Piperlongumine downregulates the expression of HER family in breast cancer cells."
03/12/2015 - "Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer."

01/01/2021 - "Metastasis of 4T1 cells to the lungs of BALB/c mice was dramatically reduced in piperlongumine-treated animals. "
01/01/2020 - "Several preclinical studies have documented the anticancer potential of piperlongumine through its targeting of multiple molecular mechanisms, such as cell cycle arrest, anti-angiogenesis, anti- invasive and anti-metastasis pathways, autophagy pathways, and intrinsic apoptotic pathways in vitro and in vivo. "
01/01/2021 - "These findings reveal a previously unknown capacity of low dose piperlongumine to interfere with TNBC metastasis via an oxidative stress-dependent mechanism."
07/13/2011 - "Moreover, piperlongumine potently inhibits the growth of spontaneously formed malignant breast tumours and their associated metastases in mice. "
07/15/2021 - "The present study evaluated the functions of Piperlongumine (PL) in osteosarcoma (OS) cell growth and metastasis both in vitro and in vivo. "

01/01/2014 - "In this study, we investigated the potential of a known ROS inducer, piperlongumine (PPLGM), a bioactive agent found in long peppers, to induce pancreatic cancer cell death in cell culture and animal models. "
03/01/2018 - "Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis."
06/01/2016 - "Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways."
03/01/2016 - "The aim of this study was to investigate whether piperlongumine, a natural product isolated from the fruit of the pepper Piper longum, has any efficacy against human pancreatic cancer when used either alone or in combination with gemcitabine in vitro and in a xenograft mouse model. "
01/01/2021 - "Materials & methods: TSN loaded with paclitaxel (PTX) or piperlongumine (PL) were prepared using high-pressure homogenization and tested for immunogenicity in healthy animals and antitumor properties in pancreatic cancer xenograft models. "

10/13/2023 - "In this study, we evaluated the antitumor activities of HSP90 inhibitors in combination with piperlongumine in colon cancer cells. "
01/01/2023 - "In this study we show that like other NR4A1 inverse agonists piperlongumine inhibited RKO, SW480 and HCT116 colon cancer cell growth migration and invasion and induced apoptosis. "
10/13/2023 - "We show that combination treatment with HSP90 inhibitors and piperlongumine displayed strong synergistic interaction in colon cancer cells. "
09/01/2013 - "Activation of ERK signaling and induction of colon cancer cell death by piperlongumine."
08/01/2022 - "These results demonstrate that mitochondrial uncoupling is a metabolic feature of CD133(+) colon cancer cells that provides protection against piperlongumine therapy by suppressing mitochondrial ROS generation. "