CGP 56999A

1.	Seizures (Seizure) 05/01/2008 - "Seizures induced by CGP56999A originated mostly from the hippocampus and amygdala, and were associated with no mortality" 08/27/1997 - "In rats a dose of 3 mg/kg CGP 56999A (i.p.) induced convulsions of tonic-clonic nature" 05/01/2008 - "The aim of this study was to investigate the long-term alterations of synaptic transmission and seizure susceptibility in the hippocampus after early-life seizures induced by systemic injection of a GABA(B)-receptor antagonist CGP56999A in immature rats" 02/01/2000 - "The GABA(B) receptor antagonist CGP 56999 and kainic acid induced a similar incidence of seizures in GAERS and NE rats and predominantly activated the hippocampus" 08/13/1997 - "In non-epileptic control rats, intraperitoneal injections of higher doses of CGP 36742 (800-2400 mg/kg) and CGP 56999 (3-6 mg/kg) induced delayed clonic convulsions, which were suppressed by pretreatment with baclofen" Get all the results and reference details, order at left...
2.	Absence Epilepsy (Absence Seizure) 09/01/2000 - "Administration of a GABA(B) antagonist, CGP 56999, at a dose which blocks absence seizures in GAERS, caused a shift to faster frequencies of the EEG in both GAERS and control rats" 08/13/1997 - "In Wistar rats with spontaneous non-convulsive absence epilepsy, absence seizures were dose dependently suppressed by intraperitoneal administration of the GABAB receptor antagonists CGP 36742, 50-400 mg/kg, and CGP 56999, 0.25-0.75 mg/kg, and by bilateral microinjections of the same compounds into the lateral nuclei of the thalamus" Get all the results and reference details, order at left...
2 Diseases and 5 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	GABA-B Receptors (Receptor, GABA-B)
2.	Kainic Acid (Kainate)
3.	gamma-Aminobutyric Acid (GABA)
4.	Baclofen
5.	(3-aminopropyl)(n-butyl)phosphinic acid
5 Drugs and Important Bio-Agents and 4 more articles analyzed in the Research Interface, order at left...

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