|1.||Chromosome Aberrations (Chromosome Abnormalities)
11/01/1984 - "Treatment with apholate increased the frequency of chromosomal aberrations significantly (P less than 0.001). "
11/01/1984 - "Sister-chromatid exchanges and chromosomal aberrations in lymphocytes of male albino rats treated with an alkylating agent, apholate (NSC 26, 812; ENT 26, 316)."
11/01/1984 - "A lymphocyte culture system was used to study the frequency of chromosomal aberrations and SCEs at various time intervals after an intraperitoneal injection of apholate (0.5 mg/kg b.w.) in male albino rats. "
01/01/1970 - "Apholate-sterilized laboratory males were not only compatible with wild females but could even induce the same level of sterility in them and were fully as competetive in mating as normal wild males. "
01/01/1969 - " the polyaziridinyl compounds, non-toxic doses of apholate could produce about 100% sterility with larval treatment. "
01/01/1967 - "The investigation discussed in the present paper has shown that apholate (2,2,4,4,6,6-hexahydro-2,2,4,4,6,6-hexakis (1-aziridinyl)-1,3,5,2,4,6-triazatriphosphorine) can induce sterility rates of from 43% to 95% in Culex pipiens fatigans Wiedemann treated in the larval stage, and from 80% to 100% in C. "
07/31/1964 - "Increased resistance to the sterilizing effects of apholate was observed in two colonies of Aedes aegypti (L.) exposed in the larval stage of each generation to concentrations of apholate that induced about 90 to 40 percent sterility in the eggs laid by the ensuing adults."
01/01/1969 - "The probable reasons for the recovery from sterility of apholate-treated males and the more lasting sterility of tepa-treated males are discussed."
11/01/1983 - "Myko 63 was found to significantly retard primary and secondary tumor growth and to prolong the survival rates in each of the nine models employed. "
11/01/1983 - "The antineoplastic activity of hexaziridinocyclotriphosphazene (Myko 63) has been investigated in a panel of murine ascitic and solid tumors. "
11/01/1983 - "The antineoplastic activity of hexaziridinocyclotriphosphazene (Myko 63) in murine tumors."
09/01/1980 - "the spectrum of N3P3Az6 (code name MYKO 63)--which exhibits noticeable activity on murine P 388, L 1210 and B 16 tumors--appeared to be remarkably simple, as most of the fragmentations arose from successive losses of the aziridino radicals. "