T 506

Also Known As:

5-fluoro-2'-deoxy-3'-O-oleoyluridine-5'-(2-trimethylammoninoethyl)phosphate; T-506; 5'-Uridylic acid, 2'-deoxy-5-fluoro-, mono(2-(trimethylammonio)ethyl) ester, hydroxide, inner salt, 3'-(9-octadecenoate), (Z)-

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - Uracil Nucleotides: 40
        Deoxyuracil Nucleotides: 1
        Fluorodeoxyuridylate: 99
        T 506: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Deoxyribonucleotides: 132
    - Deoxyuracil Nucleotides: 1
      - Fluorodeoxyuridylate: 99
        T 506: 4
  - Pyrimidine Nucleotides: 48
    - Uracil Nucleotides: 40
      - Deoxyuracil Nucleotides: 1
        Fluorodeoxyuridylate: 99
        T 506: 4

Experts

1.	Kinoshita, R: 1 article (06/2012)
2.	Matsuura, T: 1 article (06/2012)
3.	Miyamoto, N: 1 article (06/2012)
4.	Nihongi, H: 1 article (06/2012)
5.	Shimizu, S: 1 article (06/2012)
6.	Shirato, H: 1 article (06/2012)
7.	Takao, S: 1 article (06/2012)
8.	Toramatsu, C: 1 article (06/2012)
9.	Umegaki, K: 1 article (06/2012)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 07/01/1991 - "These data suggested that if the side effect could be overcome, T-506 would be useful clinically for the treatment of gastrointestinal cancers or hepatic metastases." 05/01/1997 - "5'-DFUR and T-506 showed the highest rate of inhibition of hepatic metastasis, suggesting that these drugs would be effective for the prophylactic treatment of metastatic disease. " 05/01/1997 - "At the treatment regimens employed for 5'-DFUR (1.0 mmol/kg/day, p.o., daily from days 1 to 7), UFT (0.1 mmol/kg/day, p.o., daily from days 1 to 7), and T-506 (0.074 mmol/kg/day, i.v., days 1, 4, 7, and 10), complete inhibition of hepatic metastasis was obtained in six out of seven mice (85.7%) with 5'-DFUR, and in five out of six mice (83.3%) with T-506. " 07/01/1991 - "T-506 and 5'-DFUR suppressed completely the metastases of 5 of 6 (83.3%) mice and 6 of 7 (85.7%), respectively. " 07/01/1991 - "[Antitumor activity of T-506, a novel synthetic FUDR derivative, on murine colon cancer and its hepatic metastasis]."
2.	Neoplasms (Cancer) 06/01/2012 - "SU-E-T-506: Dosimetric Study for Shallow-Seated Tumor Using Passive/active Scanning Proton Beam."
3.	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 07/01/1991 - "These data suggested that if the side effect could be overcome, T-506 would be useful clinically for the treatment of gastrointestinal cancers or hepatic metastases."
4.	Colonic Neoplasms (Colon Cancer) 07/01/1991 - "We studied antitumor activity of T-506 by i.v. injection against mouse colon cancer, colon 26. " 07/01/1991 - "[Antitumor activity of T-506, a novel synthetic FUDR derivative, on murine colon cancer and its hepatic metastasis]."
5.	Body Weight (Weight, Body) 07/01/1991 - "However, since the loss of body weight was more marked in T-506 than in the other two drugs, the side effect was thought to be a serious problem. "

Related Drugs and Biologics

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3.	Therapeutic Uses
4.	Vaccines
5.	Pyrimidines
6.	Floxuridine (FUdR)