BMY 7378
has high affinity, selectivity & low intrinsic activity at the 5-HT(1A) receptor in hippocampal membranes
Also Known As:
8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-8-azaspiro(4.5)decane-7,9-dione; BMY-7378
Networked: 18
relevant articles (2 outcomes,
0 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Villalobos-Molina, Rafael:
2 articles
(01/2020 - 11/2004)
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2. | Andrade-Jorge, Erik:
1 article
(01/2020)
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3. | Estrada-Soto, Samuel E:
1 article
(01/2020)
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4. | Gallardo-Ortíz, Itzell A:
1 article
(01/2020)
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5. | Jiménez-Flores, J Rafael:
1 article
(01/2020)
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6. | Martínez-Aguilar, Luisa:
1 article
(01/2020)
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7. | Ramírez-Hernández, Diana:
1 article
(01/2020)
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8. | Rodríguez, Jessica E:
1 article
(01/2020)
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9. | Saucedo-Campos, Alberto D:
1 article
(01/2020)
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10. | Touyz, Rhian M:
1 article
(01/2020)
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Related Diseases
1. | Motion Sickness (Airsickness)
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2. | Alzheimer Disease (Alzheimer's Disease)
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3. | Hypothermia
03/01/1993
- " In contrast, BMY 7378, which shows low efficacy at postsynaptic 5-HT1A receptors but high efficacy at presynaptic 5-HT1A receptors, elicited only mild hypothermia. " 07/01/1992
- " 4. Partial agonist properties of BMY 7378 at postsynaptic sites were also indicated by doses for hypothermia being much greater than those for hyperphagia i.e., ED50 (hypothermia) greater than 2 mg kg-1, ED50 (hyperphagia) = 0.010 mg kg-1. " 07/01/1992
- " 2. BMY 7378 (8 mg kg-1, s.c.) and the 5-HT1A agonist (8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), 0.10 and 0.25 mg kg-1 s.c.) also caused hypothermia. " 02/01/2008
- " The alpha(1A)-adrenoceptor antagonist RS 100329 (0.1 mg kg(-1)), or the alpha(1D)-adrenoceptor antagonist BMY 7378 (0.5 mg kg(-1)) given alone, did not reveal a hypothermia to MDMA, but the combination of the two antagonists revealed a significant hypothermia to MDMA. " 02/07/1991
- " These results suggest that NAN-190 is a pure antagonist of 8-OH-DPAT-induced hypothermia in rats and that BMY 7378 and WB 4101 are, respectively, a partial agonist and an agonist in this test.(ABSTRACT TRUNCATED AT 250 WORDS)"
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4. | Hypotension (Low Blood Pressure)
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5. | Renal Insufficiency (Renal Failure)
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Related Drugs and Biologics
Related Therapies and Procedures