BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.

Abstract

The putative 5-HT1A receptor antagonist BMY 7378 (3-100 micrograms.kg-1 i.v.) caused reductions in blood pressure, heart rate and efferent renal nerve activity in anaesthetised cats. Similar effects were produced by the selective 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT 1-10 micrograms.kg-1 i.v.). The sympatho-inhibitory effects of BMY 7378 and 8-OH-DPAT, but not those of clonidine were reversed by the non-selective 5-HT1A receptor antagonist, spipirone (1 mg.kg-1 i.v.). It is concluded that BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.

• Authors: C M Stubbs, H E Connor, W Feniuk
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 197 Issue 1 Pg. 113-6 (May 02 1991) ISSN: 0014-2999 [Print] Netherlands
• PMID: 1832639 (Publication Type: Journal Article)

Chemical References

• Piperazines
• Receptors, Serotonin
• Sympatholytics
• Tetrahydronaphthalenes
• Spiperone
• 8-Hydroxy-2-(di-n-propylamino)tetralin
• BMY 7378

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin
• Anesthesia
• Animals
• Blood Pressure (drug effects)
• Cats
• Female
• Heart Rate (drug effects)
• Kidney (drug effects, innervation)
• Male
• Piperazines (pharmacology)
• Receptors, Serotonin (drug effects)
• Spiperone (pharmacology)
• Sympathetic Nervous System (drug effects)
• Sympatholytics (pharmacology)
• Tetrahydronaphthalenes (pharmacology)