cob(I)alamin adenosyltransferase

product of CblA gene; metabolic disorders due to deficient methylmalonyl-CoA mutase activity, a vitamin B12 (or cobalamin; Cbl)-dependent enzyme, resulting in some forms of methylmalonic aciduria; RefSeq NM_052845

Also Known As:

deoxyadenosyltransferase; vitamin B12s adenosylating enzyme; vitamin B12s adenosyltransferase

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Alkyl and Aryl Transferases: 180
      - cob(I)alamin adenosyltransferase: 3

Experts

1.	Briso-Montiano, Á: 1 article (01/2022)
2.	Desviat, L R: 1 article (01/2022)
3.	Morato, E: 1 article (01/2022)
4.	Pérez, B: 1 article (01/2022)
5.	Richard, E: 1 article (01/2022)
6.	Rodríguez-Pombo, P: 1 article (01/2022)
7.	Ruiz-Sala, P: 1 article (01/2022)
8.	Ugarte, M: 1 article (01/2022)
9.	Vilas, A: 1 article (01/2022)
10.	Dobson, C Melissa: 1 article (04/2006)

Related Diseases

1.	Methylmalonic acidemia 01/15/1981 - "The defect in the cbl B class of human methylmalonic acidemia: deficiency of cob(I)alamin adenosyltransferase activity in extracts of cultured fibroblasts." 04/01/2006 - "ATP:cob(I)alamin adenosyltransferase (MMAB protein; methylmalonic aciduria type B) is an enzyme of vitamin B(12) metabolism that converts reduced cob(I)alamin to the adenosylcobalamin co-factor required for the functional activity of methylmalonyl-CoA mutase. "
2.	Methylmalonic aciduria cblB type 01/01/2022 - "Methylmalonic aciduria cblB type (MMA cblB type, MMAB OMIM #251110), caused by a deficiency in the enzyme ATP:cob(I)alamin adenosyltransferase (ATR, E.C_2. 5.1.17), is a severe metabolic disorder with a poor prognosis despite treatment. "

Related Drugs and Biologics

1.	Enzymes
2.	Adenosine Triphosphate (ATP)
3.	Vitamin B 12 (Cyanocobalamin)
4.	Proteins (Proteins, Gene)
5.	Methylmalonyl-CoA Mutase
6.	cobamamide (adenosylcobalamin)